What is the physiological role of PAX5?
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PAX5 plays a crucial role in various physiological processes related to B-cell development and function. It acts as a positive transcription factor for GINS1 expression, controls gene expression profiles essential for cellular processes like viability and differentiation, and is pivotal for B-cell commitment and maintenance. In mature B cells, PAX5 promotes humoral immunity by facilitating differentiation and survival through posttranscriptional down-regulation of PTEN expression. Additionally, PAX5 has been found to have a negative role in osteoclastogenesis, inhibiting osteoclast differentiation and bone resorption. These diverse functions highlight the multifaceted role of PAX5 in regulating various aspects of B-cell biology, immunity, and bone metabolism.
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| Papers (4) | Insight |
|---|---|
| Pax5 negatively regulates osteoclastogenesis by downregulating Blimp1, inhibiting OC differentiation and bone resorption, contributing to an osteopetrotic-like bone phenotype with increased bone density and strength. | |
| PAX5 plays a crucial role in regulating gene expression profiles essential for cellular processes like viability, proliferation, and differentiation, particularly in B-cell development and cancer pathologies. | |
| PAX5 acts as a positive transcription factor for GINS1, regulating B-cell proliferation. It plays a crucial role in B lymphopoiesis and is implicated in DLBCL progression through GINS1 upregulation. | |
13 Citations | PAX5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation, facilitating mature B cell differentiation, survival, and humoral immunity in the body. |
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