What is the role of aspartic acid in the paratope and epitope of antibodies?
Best insight from top research papers
Aspartic acid plays a role in the paratope and epitope of antibodies. It is involved in the specific interaction between amino acids at the paratope-epitope interface . The predictability of antibody-antigen binding relies on the existence of structural units that are universally shared among antibody-antigen complexes . A vocabulary of paratope-epitope interactions has been identified, which is compact, immunity-specific, and distinct from non-immune protein-protein interactions . This vocabulary enables the machine learnability of paratope-epitope interactions . While the specific role of aspartic acid in the paratope and epitope is not explicitly mentioned in the abstracts, its involvement in the interaction between amino acids suggests that it may contribute to the binding between antibodies and antigens.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The paper does not provide information about the specific role of aspartic acid in the paratope and epitope of antibodies. | |
| The provided paper does not mention the role of aspartic acid in the paratope and epitope of antibodies. | |
11 Citations | The provided paper does not specifically mention the role of aspartic acid in the paratope and epitope of antibodies. |
74 Citations | The provided paper does not specifically mention the role of aspartic acid in the paratope and epitope of antibodies. |
| The provided paper does not mention the role of aspartic acid in the paratope and epitope of antibodies. |
Related Questions
Aspartic acid is upregulated or downregulated in CRC ?5 answersAspartate, also known as aspartic acid, plays a significant role in various aspects of colorectal cancer (CRC) based on the provided research contexts. Studies indicate that aspartate can alleviate colonic epithelial damage by promoting intestinal stem cell (ISC) proliferation and differentiation, thus aiding in the recovery from colitis-induced injury. Additionally, research highlights that aspartate supplementation can improve the colonic morphology, reduce inflammation, and enhance antioxidant-related gene expression in a mouse model of dextran sodium sulfate (DSS)-induced colitis, indicating a beneficial effect on gut health. Therefore, while the specific regulation of aspartate in CRC is not explicitly mentioned in the contexts, the overall findings suggest a positive impact of aspartate in mitigating colonic damage and inflammation, which could be beneficial in the context of CRC.
What is the importance of Glutamine amino acid in antibodies?5 answersGlutamine amino acid is important in antibodies because it can be functionalized with drugs, which allows for targeted drug delivery and treatment of diseases and conditions. Glutamine is also a preferred respiratory fuel for rapidly proliferating cells, such as enterocytes and lymphocytes, and serves as a carrier of nitrogen between tissues. Additionally, glutamine is crucial for the proliferation of bone marrow-derived cells and plays a role in immune cell function. Furthermore, glutamine has unique metabolic functions, including being a precursor for the synthesis of amino acids, proteins, nucleotides, and other biologically important molecules. It is also involved in regulating protein synthesis, protein degradation, and glycogen synthesis. The importance of glutamine in antibodies lies in its role in cellular metabolism, immune cell function, and as a carrier of nitrogen, making it essential for antibody production and function.
What is the role of aspartic acid in the stability of antibodies?5 answersAspartic acid (Asp) plays a significant role in the stability of antibodies. Buried aspartic acid residues in proteins form hydrogen bonds and potential ionic interactions with other protein groups, contributing to the Gibbs free energy of proteins. The stability of therapeutic monoclonal antibodies (mAbs) is crucial for their development into marketed products. Asn and Asp residues in the variable domains of antibodies are prone to degradation via deamidation and isomerization, but the factors responsible for this degradation are not well understood. The conformational flexibility, size of the C-terminally flanking amino acid residue, and secondary structural parameters of Asn and Asp residues in the complementarity-determining regions (CDRs) of mAbs are correlated with their degradation propensities. Additionally, the interaction between Asp and hydrophobic residues contributes to the suppression of aggregation in immunoglobulin (IgG1). These findings provide insights into the role of aspartic acid in the stability of antibodies and can aid in the development of stable therapeutic proteins.
How does mutation of aspartic acid increase binding affinity in antibodies?5 answersMutation of aspartic acid can increase binding affinity in antibodies through the introduction of charged residues into the framework region of the antibody. The introduction of basic amino acid residues, such as lysine, can improve the affinity of the antibody. On the other hand, the introduction of acidic residues, such as glutamic acid, can weaken the interaction. The improvement in affinity is achieved by altering the balance between the association rate constant (kon) and the dissociation rate constant (koff). Additionally, thermodynamic analysis reveals differences in the enthalpic energy change following the formation of the encounter complex with the antigen, suggesting distinct mechanisms for affinity improvement. This strategy provides a versatile and simple means to enhance antibody affinity.
What are the active substance in aspartame?5 answersAspartame is the active substance in aspartame.
What is role of aspartate in cocaine addiction?5 answersThe role of aspartate in cocaine addiction is not mentioned in the provided abstracts.