What is the significance of metabolism in chemical carcinogenesis?
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Metabolism plays a significant role in chemical carcinogenesis. Chemical carcinogens interact with DNA, RNA, and proteins in human tissue, leading to genetic mutation and changes in genome transcription, which initiate carcinogenesis . The metabolism of carcinogens, especially their bioactivation, is primarily carried out by cytochrome P450 enzymes, with six specific P450 enzymes accounting for the majority of activation reactions . Enzyme induction, a phenomenon where chemicals modulate the metabolism of carcinogens, has been observed, and cytochrome P450 enzymes are involved in both bioactivation and detoxification of carcinogens . Humans exhibit interethnic and interindividual variability in their capacity to activate or inactivate carcinogens due to genetic variability in enzymes involved in carcinogen metabolism . Therefore, understanding the role of individual enzymes in chemical carcinogenesis is crucial for assessing risk, molecular epidemiology, and developing chemoprevention strategies .
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2 Citations | Metabolism plays a crucial role in chemical carcinogenesis as it affects the concentration and formation of carcinogens and their metabolites in the body. |
Open access•Journal Article 47 Citations | Metabolism plays a significant role in chemical carcinogenesis as it affects the activation or inactivation of carcinogens in the body. |
75 Citations | Metabolism plays important roles in chemical carcinogenesis, both in the activation and detoxification of carcinogens. |
219 Citations | Metabolism plays a significant role in modulating the carcinogenic properties of chemicals by activating pro-carcinogens to exert genotoxic effects. |
| Metabolism plays a significant role in chemical carcinogenesis by activating carcinogens and promoting the growth of cancer cells. |
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