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What's the best time to take zinc 50 mg? 

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In fasting state, the parameters were comparable to those previously collected in the same subjects with oral 45 mg zinc as sulfate, except with very significantly higherCmax and area under curve (AUC), showing a better bioavailability for zinc in the commercial form.
Zinc supplementation with a dose as low as 3 mg/d increased plasma zinc concentrations and reduced diarrhea incidence in the study population.
Mild to moderate zinc deficiency can be best detected through a positive response to supplementation trials.
The results of the present experiment indicate that the zinc tolerance test, that is, an unequivocal rise in serum zinc following per oral administration of this metal, provides the best indication of zinc status.
These results indicate that short-term low-level zinc supplementation (total intake 40 mg/d) is not detrimental to health.
This represents 3.5-8% of the LOAEL for zinc of 50 mg/day and would not be important as compared to other sources zinc intake.
Even when CRP and time were taken into account, zinc supplementation increased plasma zinc concentration from admission to 72 h. When available, plasma zinc concentrations should be interpreted with concurrent measures of the acute phase response such as CRP.
(These interactions have already been observed at an intake of 50 mg.) Thus, the range between essential and potential deleterious intake of zinc is rather narrow.
The findings indicate that a daily dose of 75 mg must be divided into at least two doses to be effective, and that the 64copper procedure is more sensitive to zinc dose than copper balance.
However, in every tissue, 65Zn retention from a single oral dose declined sharply with duration of added zinc feeding to 21 days, indicating a continuing adaptation in zinc metabolism for at least this period of time.
The results suggest that total EZP mass is maintained when dietary zinc is reduced to 4.6 mg/d over a 10-wk period.
Increases in aqueous zinc doses >20 mg result in relatively small and progressively diminishing increases in AZ postabsorptively in healthy adults.
Humans absorbed zinc more efficiently from low-zinc diets and adapted to further increase zinc absorption after consuming low-zinc, low-phytate diets for several weeks.