Showing papers on "Carcinosarcoma published in 1991"

Papillary carcinoma of thyroid with exuberant nodular fasciitis-like stroma. Report of three cases

Abstract: Three examples of an unusual morphologic variant of papillary thyroid carcinoma (PTC) are reported. The presence of a prominent stromal component resulted in low-power microscopic appearances resembling fibroadenoma, phyllodes tumor, or fibrocystic disease of the breast in two cases. The carcinomatous component grew in the form of anastomosing narrow tubules, clustered glands, solid sheets with or without squamous differentiation, and/or papillae, and exhibited the typical nuclear features of PTC. The abundant stroma had a nodular fasciitis-like quality and was composed of short fascicles of spindle cells separated by varying amounts of mucoid matrix, collagen, and extravasated red blood cells; this was interpreted as an exuberant mesenchymal reaction to the carcinoma. The importance of recognizing this variant of PTC is that, when one encounters a fibroproliferative lesion of the thyroid, a diligent search should be made for papillary carcinoma. This variant also must be distinguished from the vastly more aggressive papillary carcinomas with anaplastic transformation and the so-called carcinosarcomas.

Comparative investigation of c-erbB2/neu expression in head and neck tumors and mammary cancer.

Abstract: Normal tissues, primary tumors, and metastases of mammary and salivary glands and oral/laryngeal mucosa have been analyzed with Northern-blots employing 32P-labeled RNA probes for the expression of the neu oncogene. Neu oncogene expression of a mRNA species of 4.6 kilobases was found in all normal salivary (five) and mammary glands (four) as well as in two normal or inflamed samples of tongue mucosa. This expression was regarded as baseline activity of the neu gene for the respective tissues and was used as standard for the evaluation of benign and malignant tumors. None of 14 squamous cell carcinomas of the oral and laryngeal mucosa showed enhanced neu transcription level. Five fibroadenomas, one benign variant of phylloid tumor, one carcinosarcoma, and one of two proliferative fibrocystic diseases of the breast showed lacking or normal baseline expression of the neu oncogene, as did one monomorphous cystadenolymphoma of the parotid gland. In contrast, four parotid pleomorphic adenomas and one salivary gland adenocarcinoma showed enhanced neu expression. For mammary adenocarcinomas, increased neu oncogene expression concerned ten of 34 cases--all being variants of ductal carcinomas--and all metastases analyzed (six) deriving from three primaries. One adenoid cystic carcinoma also showed enhanced neu expression. Neu overexpression may reflect accidents of genomic reconstitutional events occurring regularly within the differentiation pathway of epithelial/myoepithelial cells. This assumption was supported by further immunohistochemical analysis which showed stainings of myoepithelial and myoepithelia-like cell populations in tumors, especially pleomorphic adenomas and adjacent normal-looking tissues.

Carcinosarcoma of bladder following long-term cyclophosphamide therapy.

Abstract: Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkin's lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period.

The changing phenotypic appearance of a malignant vulval neoplasm containing both carcinomatous and sarcomatous elements.

Abstract: We describe the changing phenotypic appearance over a 7-year period of a malignant neoplasm of the vulva. This lesion was studied by light and electronmicroscopy and immunohistochemical techniques. The tumour contained both carcinomatous and sarcomatous elements including osteosarcomatous differentiation. To our knowledge osteosarcomatous differentiation has not been reported previously at this site. We submit that the best term for this type of neoplasm, based on tumour differentiation rather than reputed histogenesis, is carcinosarcoma. Tumours such as these occurring in the female genital tract should be distinguished from metastatic mixed Mullerian tumours.

Malignant mixed tumor (carcinosarcoma) of parotid gland diagnosed by fine‐needle aspiration biopsy

Abstract: True malignant mixed tumor (carcinosarcoma) of salivary gland is a very rare neoplasm. Only one brief account of the Fine-Needle Aspiration Biopsy (FNAB) cytologic findings of this tumor was found in the literature. The authors report a case of malignant mixed tumor (chondrosarcoma and epidermoid carcinoma) arising from the left parotid gland in an 84-yr-old man, which was definitely diagnosed by FNAB. The cytologic findings and differential diagnosis are discussed.

Malignant mixed tumor (malignant ameloblastoma and fibrosarcoma) of the maxilla.

Abstract: We present a rare case of carcinosarcoma (malignant ameloblastoma and fibrosarcoma) of the left maxilla that developed in a 63-year-old Japanese man. The tumor recurred repeatedly despite multiple surgical removals, radiotherapy, and chemotherapy and led to progressive cachexia; the patient died after 3.8 years of hospitalization. Histopathologic examination revealed that the recurrent tumor was carcinosarcoma, which had progressed from malignant ameloblastoma with fibroma. An autopsy confirmed the diagnosis of malignant mixed tumor with lung metastasis of malignant ameloblastoma and fibrosarcoma.

Carcinosarcoma-like mural nodule in an ovarian mucinous tumour.

Abstract: ively). The first case presented with weight loss and leucocytosis, the second with persistent diarrhoea and intermittent abdominal pain. In both cases the symptoms resolved on removal of the cysts'. The histogenesis of these lymphoepithelial cysts is not proven. However, the suggestion that they arise from a portion of a branchial cleft that is misplaced, and fused with the pancreas during embryogenesis, would account for the distinctive histological features and peculiar anatomical location'. Congenital cysts of the pancreas usually present in the newborn period but can also occur in adults. Despite the probable congenital nature of the cysts described, reported pancreatic cysts of congenital origin do not include lymphoepithelial cysts, suggesting that these are indeed rare.

A color atlas of breast histopathology

Abstract: 1: Normal breast. 2: Fibrocystic disease Cyst Epitheliosis Adenosis Radial scar. 3: Papilloma Solitary intraductal papilloma Multiple intraductal papilloma Juvenile multiple intraductal papilloma Microscopic papilloma Papillary adenoma of the nipple. 4: Duct ectasia. 5: Fibroepithelial tumours Fibroadenoma Cystosarcoma phyllodes Carcinosarcoma. 6: Miscellaneous benign entities Haemangioma Fibromatosis Breast hamartoma Granulomatous mastitis Spontaneous breast infarction Fat necrosis Fibrous disease of the breast Granular cell tumour Gynaecomastia. 7: Carcinomas Non invasive carcinoma Invasive carcinoma Paget's disease of the nipple Combinations of histological types. 8: Miscellaneous malignant tumours Angiosarcoma Non-Hodgkin's malignant lymphoma Granulocytic sarcoma Metastasis to the breast from a malignant tumour localized elsewhere. 9: Axillary lymph node Lymph node metastasis Benign inclusions in lymph nodes.

Pleomorphic carcinoma of the small bowel. The limitations of immunohistochemical specificity.

Abstract: Summary We report 3 cases of poorly differentiated tumors of the small bowel with histological, immunohistochemical, and ultrastructural studies. The patients were male, aged 45, 57, and 63. In all 3 cases, histological features of spindle cell, epithelioid cell and giant cell areas favoured a diagnosis of carcinoma, although a malignant stromal tumor could not be firmly excluded. Immunohistochemistry demonstrated in the 3 cases a strong expression of both “epithelial” (cytokeratin) and “stromal” (vimentin) markers; one tumor expressed the epithelial membrane antigen, and another one desmin. Electron microscopy showed no specific features in one case. The case positive for desmin demonstrated intracytoplasmic lumina, allowing the diagnosis of carcinoma. In spite of a non-specific immunohistochemical pattern, we finally considered these 3 tumors as of epithelial origin, corresponding to the rare and recently described pleomorphic carcinoma of the small bowel. This report emphasizes the difficult diagnosis of some poorly differentiated tumors, particularly in the gastro-intestinal tract. Such problems had until recently been resolved by ultrastructural and mostly by immunohistochemical studies. However, an increasing number of reports, together with our 3 cases, show unexpected reactivity of tumors with theoretically specific immunoreactions, such as those directed against intermediate filaments. Coexpression of intermediate filaments could be due to cross reactivity of molecules bearing common epitopes, or to the presence of different filaments in the same cell type; recent immunoblotting studies favour this latter hypothesis.

Carcinosarcoma of the stomach with endocrine differentiation. A case report.

Abstract: An unusual tumor was observed in a 67-year-old man. Microscopically, the tumor was composed of epithelial cells forming glands (CEA, EMA-positive) and spindle-shaped cells (vimentin-positive). A third component was a cell population ultrastructurally characterized by intracytoplasmic granules surrounded by a membrane; these proved to be chromogranin A-positive in the immunoperoxidase study.

Mixed mesodermal tumours of the ureter.

Abstract: This report is of a 78 year-old male with a mixed mesodermal tumour of the left ureter. A comparison of all reported patients with such neoplasms has been made in the discussion, in an attempt at characterization of this neoplasm.

Carcinosarcoma of the lung. A case-history of disseminated disease and review of the literature.

Abstract: A case of disseminated pulmonary carcinoma is presented. Metastases of both carcinoma and sarcoma were confirmed via light microscopy and immunohistological examination. Our observations on this rare tumour are compared with a review of the literature.

Bladder carcinosarcoma with osteosarcomatous differentiation

Abstract: Osteoid tissue can eventually be identified outside the bone skeleton adopting the form of metastasis, osteoid metaplasia or primitive osteosarcoma. This latter presentation is most frequently located in soft tissues and exceptionally at the visceral level. The term used for any of these forms is extra-bone osteogenic sarcoma. This paper reports the case of a 62 year-old female patient diagnosed with vesical urothelial carcinosarcoma treated with external radiotherapy. After a disease-free period of 20 years the patient developed osteosarcomatous-differentiated vesical carcinosarcoma. A literature review is made to analyze, from a clinical and histopathological perspective, several items of interest presented by this pathology. The role of sarcomatous radio-induction is also highlighted. Finally, we emphasize the relevance of using radical treatments from the start, so as to restrain the highly malignant potential of this condition.

True malignant mixed tumor (carcinosarcoma) of palatal minor salivary gland origin.

Abstract: True malignant mixed tumor (carcinosarcoma) of salivary gland origin is exceedingly rare and is distinguishable from the more frequently occurring carcinoma ex pleomorphic adenoma. This paper reports a case of true malignant mixed tumor originating from a palatal minor salivary gland of a 55-year-old male. Histologically, nests of poorly differentiated adenocarcinoma were scattered in a sarcomatous background which partially showed an unequivocal chondrosarcoma. Clinical course of the present patient suggested that a pre-existing benign minor salivary gland lesion developed to a carcinosarcoma.

Carcinosarcome de la vessie et métastase rénale.

Abstract: A 74 year-old woman developed a polypoid tumor of the bladder which was discovered by hematuria. Upon histological examination, the tumor was shown to be a carcinosarcoma with a weak epithelial composition confirmed by immunolabelling with keratin and was composed essentially of chondrosarcomatous material. Six months later, the patient developed metastases in the kidney, in the paravertebral muscles, and in the right para-ureteral lymph nodes. There are 55 cases of carcinosarcoma of the bladder described in the literature [3, 20, 22]. It is a tumor found more frequently in men than in women, between the ages of 33 to 83. The prognosis is very gloomy .70% death rate within 2 years), but it seems to be improved by radical cystectomy and adjuvant therapy.

Carcinosarcoma with chondromatous differentiation of the bladder

Abstract: We report a case of carcinosarcoma whose most striking feature was its markedly chondroid elements that initially prompted us to suspect a chondrosarcoma. The clinical features and treatment of this rare tumor type are briefly discussed.

Polypoid adenosquamous carcinosarcoma of the epiglottis with blastomatous features.

Abstract: A case is reported of polypoid adenosquamous carcinosarcoma with blastomatous features arising in the epiglottis. A 69-year-old man with hoarseness and sore throat was found to have a six cm pedunculated mass located on the epiglottis. Upon examination by light microscopy, it was found that the tumor was composed of not only well to poorly differentiated in situ and invasive squamous cell carcinoma but also adenocarcinoma with blastomatous features and a malignant primitive stroma, with features of undifferentiated sarcoma and focal chondrosarcomatous differentiation. To the best of our knowledge, this appears to be the second case of laryngeal adenosquamous carcinosarcoma with blastomatous features reported in the English literature and the third case in the world literature.

A case of spindle cell (squamous) carcinoma (WHO) of the lung

Abstract: A 76-year-old man with spindle cell (squamous) carcinoma of the lung developed fatal respiratory failure after limited thoracic irradiation at a total dose of 18 Gy. He developed severe pulmonary toxicity, which presented as dry cough, dyspnea, and pulmonary infiltrates extending beyond the radiation field. Microscopically, a transitional form of squamous to spindle-shaped cells was observed in the primary tumor, located at right S8. Immunohistochemical examination showed positive staining of spindle cells for keratin, vimentin, and EMA, but not for desmin. These results indicate that the spindle cells had characteristics of squamous epithelial cells, and differed from carcinosarcoma. Distant metastatic lesions were composed of only the spindle cell component.