Showing papers on "Hypersensitivity reaction published in 1985"
TL;DR: The successful outcome following the use of corticosteroid pulse therapy in a patient with a severe phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis is described.
Abstract: In this report we describe the successful outcome following the use of corticosteroid pulse therapy in a patient with a severe phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Steroid pulse therapy may be lifesaving in a severe dermatosis, such as toxic epidermal necrolysis.
79 citations
TL;DR: Three cases of eosinophilic pneumonia are associated with bleomycin chemotherapy, and these cases appear to represent a hypersensitivity reaction resembling eosInPhilic pneumonia.
55 citations
TL;DR: Findings suggest that acute hypersensitivity reactions to cyclophosphamide are due to its metabolites and can be delineated with skin testing.
Abstract: Generalized urticaria and fever were noted in a patient with IgA (kappa) myeloma after intravenous cyclophosphamide. Intradermal skin testing revealed no reaction to cyclophosphamide and its analog, isophosphamide. However, phosphoramide mustard, a principle metabolite of cyclophosphamide, evoked an immediate wheal-and-flare response. Subsequent therapy with isophosphamide was well tolerated. These findings suggest that acute hypersensitivity reactions to cyclophosphamide are due to its metabolites and can be delineated with skin testing.
22 citations
TL;DR: The case of a patient being treated with diltiazem who developed a severe hypersensitivity reaction that presented clinically as a generalized lymphadenopathy and sowed the seeds for future studies to investigate the role of EMT in Hashimoto's disease.
Abstract: Excerpt To the editor: We report the case of a patient being treated with diltiazem who developed a severe hypersensitivity reaction that presented clinically as a generalized lymphadenopathy and s...
21 citations
TL;DR: The findings of specific lymphocyte sensitization of DPH, a clinically typical delayed hypersensitivity reaction, multinucleated histiocytes in the renal interstitium, and negative renal immunofluorescence studies for immune reactants indicate that the child's renal injury was at least partially cell-mediated.
19 citations
19 citations
01 Jan 1985
TL;DR: A local graft versus host reaction between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir).
Abstract: A local graft versus host reaction between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir). In this local mixed lymphocyte reaction mainly T-helper cells and B-cells are involved. An induction of a delayed type hypersensitivity reaction with oxazolon significantly decreases the local graft versus host reaction. Cyclosporin A depresses the local graft versus host reaction and the delayed type hypersensitivity in mice whereas Ciamexone, a 2-cyanaziridine derivative, very selectively only suppresses the local graft versus host reaction and increases the delayed type hypersensitivity.
13 citations
13 citations
TL;DR: ADA 202-718 was more effective than acetyl salicylic acid in alleviating the oedema-associated pain and did not decrease the swelling in the Freund's adjuvant induced arthritis in the rat, but reduced the pain in this model.
10 citations
TL;DR: The hypothesis that the general symptoms of tuberculous patients may be due to the action of the specific antigen upon the sensitized host can be extrapolated in order to interpret some hitherto unexplained findings that are observed in cancer hosts, as well as organ transplant recipients.
9 citations
Journal Article•
TL;DR: A 23-year-old female presented with classical features of immediate hypersensitivity reaction after contact with paw-paw (Cerica papaya) and her serum gave a positive P-K test on her siblings.
Abstract: A 23-year-old female presented with classical features of immediate hypersensitivity reaction after contact with paw-paw (Cerica papaya). She had a total serum IgE of 2500 i.u./ml. Prick tests with paw-paw extracts were positive. Her serum gave a positive P-K test on her siblings.
TL;DR: A model of Type I hypersensitivity in the conjunctiva of guinea pigs sensitized to normal rabbit serum was used to test the efficacy of 2-deoxy-D-glucose or a combination of isoproterenol and diethylcarbamazine in inhibiting conjunctival hypersensitivity.
Abstract: The release of histamine and other mediators from an immediate hypersensitivity reaction is energy dependent and cyclic AMP dependent. Drugs which inhibit the active secretion of mediators, or which may change cyclic AMP are effective in inhibiting mediator release. We used a model of Type I (immediate) hypersensitivity in the conjunctiva of guinea pigs sensitized to normal rabbit serum to test the efficacy of 2-deoxy-D-glucose or a combination of isoproterenol and diethylcarbamazine in inhibiting conjunctival hypersensitivity. After topical challenge with rabbit serum, edema was evaluated in five areas of the guinea pig conjunctiva. Controls were compared to conjunctiva pretreated with 2-deoxy-D-glucose or isoproterenol and diethylcarbamazine. Pretreatment with 2-deoxy-D-glucose or a combination of isoproterenol and diethylcarbamazine was found to inhibit the immediate hypersensitivity reaction.
Journal Article•
TL;DR: The authors review the literature about hypersensitivity to alcohol and to the different components of alcoholic drinks, especially added compounds and the appropriate sensitivity tests for making this diagnosis are described.
Abstract: The relationship of alcohol intake and urticaria is complex. The mechanism of action may be related to a hypersensitivity reaction to ethyl alcohol or to the other components of alcoholic drinks. Urticaria may also result from the pharmacological effects of alcohol or from the histamine content of the drink. The authors review the literature about hypersensitivity to alcohol and to the different components of alcoholic drinks, especially added compounds. The appropriate sensitivity tests for making this diagnosis are described.
01 Jan 1985
TL;DR: By transferring T effector cells of delayed type hypersensitivity (TDH cells) to naive recipients it is shown that CyA does not inhibit the induction of this T subpopulation but very efficently blocks its functional expression in the recipient animal.
Abstract: A substantial body of data demonstrates the immunosuppressive properties of the fungal metabolite cyclosporin A (CyA) Several T cell responses such as a mixed leukocyte reaction and lectin mitogenesis are blocked by this drug It has been suggested that CyA inhibits the first stages of the T cell responses by suppressing the T cell stimulatory signals leading to activation and proliferation It has been shown that CyA prevents the expression of receptors for T cell growth factor interleukin 2 [5] and in addition depresses the production of IL2 via a pathway involving inhibition of IL 1 The delayed type hypersensitivity reaction to various antigens is usually depressed by CyA, particularly if it is administered during the induction phase [2] However, recent investigations have shown that in various in vivo delayed type hypersensitivity models cyclosporin A may even enhance the immune response, depending on the time of administration [6] We have used contact sensitivity to 2,4dinitrofluorobenzene (DNFB) in mice as a model of delayed type hypersensitivity to study the effects of CyA on this reaction By transferring T effector cells of delayed type hypersensitivity (TDH cells) to naive recipients we were able to show that CyA does not inhibit the induction of this T subpopulation but very efficently blocks its functional expression in the recipient animal CyA may even enhance the immune response if a suppressive dose (antigen overload) of the contact sensitizer is applied to the skin
TL;DR: The mechanisms of rejection of xenogeneic grafts have received much less study, but their interpretation is important in connection with the prospects for the use of xenografts in medical practice.
Abstract: Xenogeneic transplantation into an adult animal induces a whole range of reactions leading to gradual destruction of the grafted tissue. In the modern view, cytotoxic T lymphocytes, T effector cells, and also delayed-type hypersensitivity (DTH) antibodies may participate in graft rejection [3, 8, !i, 12]. Depending on the nature of the graft, the method of transplantation (with vascular anastomoses or by free grafting), and also the level of sensitization of the recipient, each of the above components of the immune response may play a more or less important role in rejection. Evidence of the important role of DTH reactions in allograft rejection has recently been published [6, 7, i0]. The mechanisms of rejection of xenogeneic grafts have received much less study. Their interpretation is important in connection with the prospects for the use of xenografts in medical practice.
TL;DR: Synthetic PAF-acether injected intraperitoneally into sham-sensitized rats, caused dose-dependent extravasation of plasma proteins into the peritoneal fluids.
Abstract: Synthetic PAF-acether injected intraperitoneally (i.p.) into sham-sensitized rats, caused dose-dependent extravasation of plasma proteins into the peritoneal fluids. Platelet aggregating activity was detected in the peritoneal fluids. In rats that had been passively sensitized for a non-histamine mediated immediate hypersensitivity reaction, antigen challenge caused extravasation of plasma proteins into the peritoneal fluids. No platelet aggregating activity was detected in these fluids. PAF is unlikely to be the mediator of extravasation in the non-histamine mediated immediate hypersensitivity reaction in the rat.