Showing papers in "Medical Hypotheses in 1985"

TL;DR: Data showed that the consumption of fruits and vegetables, particularly those rich in vitamin C (based on content and consumption), may have offered a protective effect against deaths from CVD.

TL;DR: Since even at very high doses, ascorbate is virtually nontoxic, it may be given in the enormous doses necessary to quench almost all unwanted free radicals and oxidants.

TL;DR: The hypothesis is that the exclusive involvement of apoptosis in lymphocytotoxicity may have additional advantages in preventing virus dissemination.

TL;DR: The observation that constipation alone may induce uninhibited bladder contractions in children and is associated with recurrent urinary tract infection in childhood suggests an etiologic association.

TL;DR: Relatively low intracolonic levels of n-butyrate are associated with a low fibre diet and the presence of naturally occurring differentiating agents, such as n- butyrate, may modify the patterns of growth and differentiation of gastrointestinal tumours.

TL;DR: Re-examination of the data from the lethal 1918 pandemic armed with recent observations about the influenza virus implicates a neurovirulent influenza virus in manic-depressive disease, schizophrenia and Parkinson's disease.

TL;DR: This work proposes a mechanism by which kynurenines act to reduce the concentration of active insulin in plasma and thus give rise to a diabetic state.

TL;DR: It was found that severe measles was not associated with PEM but frequently accompanied overcrowding in Guinea-Bissau, and specific measles control, and not only improvements in nutrition, is important in high risk areas for a reduction of measles mortality.

TL;DR: Several approaches are suggested that might overcome the problem of autofluorescence and enable specific immunofluorescent detection of cellular proteins and automated analysis of alveolar macrophages.

TL;DR: When a zinc deficient woman becomes pregnant and is exposed to both the nutritional demands of the fetus and to the influence of progesterone, she will be likely to develop the manifestations of cadmium toxicity (i.e. hypertension, proteinuria, edema, etc.).

TL;DR: It is concluded that tumor rejection can be mediated not only by the direct effect of anti-tumor drugs but more effectively by the organisms mechanisms responsible for removal of undesirable tissue.

TL;DR: The Blood-Vessel Thrust Theory is a new hypothesis regarding the forces which produce the normal eruption of teeth, and the movement of 'nonerupted' teeth through bone away from their normal position in the jaws.

TL;DR: This paper elaborates on some of these in light of overlooked or recent publications and presents additional hypotheses including 2-Thioimidazoles (ERT and 2-thiourocanic acid in particular) may be immunoregulatory and ERT may be involved in the protection from oxidation (inactivation) of methionine and methamphetamineionine containing chemoattractants, hormones, tRNA, etc.

TL;DR: A number of treatments using zinc are reviewed which illustrate the effects of topically applied zinc in reducing the duration and severity of human orolabial and genital infections.

TL;DR: It is postulated here that the dementia occurring in patients with lacunar strokes is due to an ischemic leukoencephalopathy, and the term Lacunar Dementia is proposed, instead of the poorly known eponym "Binswanger disease" or the cumbersome descriptive name "subcortical arteriosclerotic encephalopathy".

TL;DR: The raised incidence of psychosis in systemic lupus erythematosus and during pregnancy both associated with raised blood polyamine levels, makes the involvement of the polyamines in psychosis more likely.

TL;DR: A review of the literature shows that the thymus is the major reason for aging of the immune system and T cell function is so affected that there is a deficit in T cell responsiveness.

TL;DR: Studying the surface lipid and epidermal lipid composition, lipid membranes can be composed which do not cause hypersensitivity reactions and form a substitute in case of deficient barrier function of the skin.

TL;DR: If some adults with ADD have responded positively to caffeine ingestion then it would be predicted that increases in reports of ADD symptoms will escalate with the rapid decline in caffeine consumption in North America.

TL;DR: A conclusion is reached that cardiogenic shock leading to acute cardiac failure is the primary final cause of death in all SIDS infants.

TL;DR: Much more than other primates, man has several features that are seen more often in aquatic than terrestrial mammals: nakedness, thick subcutaneous fat-layer, stretched hindlimbs, voluntary respiration, dilute urine etc.

TL;DR: The initial results on endogenous lectin of different tumors lead to the working hypothesis that the pattern of endogenous lectins is qualitatively and quantitatively different between different types of tumors and between tumors and normal, nonmalignant tissues.

TL;DR: It is suggested here that these age specific curves of adult cancers are mixtures of two pathologies, an inflammatory, which is prevalent in young persons, followed by neoplasia, resembling precursor-successor curves of tracer kinetics.

TL;DR: Vitamin B6 deficiency occurring at the same time as contact with carcinogens could well lead to tumour initiation and subsequent cancer development.

TL;DR: It is hypothesized that hereditary nonpolyposis colorectal cancer (HNPCC) accounts for a significant proportion of the colon cancer burden and the premalignant colonic mucosa in HNPCC patients may be comparable in many respects to the Premalignant polyps in its hereditary multiple adenomatous polyposis counterpart.

TL;DR: It is suggested that alcoholics show overhydration particularly during withdrawal and that pathological changes in the alcoholic brain are related to cerebral edema.

TL;DR: This hypothesis suggests that clinical syndromes of disordered attention may be caused by various lesions of efferent connections from hippocampal formation to nucleus accumbens, and addresses the possibility that the threshold of hippocampus to various classes of stimuli may change on a diurnal and phasic basis.

TL;DR: A chronic imbalance between the essential fatty acid metabolites arachidonic acid, gamma-linolenic acid and eicosapentaenoic Acid and of their respective eICosanoid derivatives appears to be implicated in the etiology of many intractable disease.

TL;DR: It is offered an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromonal climate to which prepubertal females are exposed, thereby affecting onset of menarche.

TL;DR: Rapid eye movement (REM) sleep seems to protect infants from developing the sudden infant death syndrome (SIDS), andryptophan - serotonin - melatonin deficiencies are suggested as a possible cause of SIDS.