Showing papers on "Lyngbya majuscula published in 1997"
TL;DR: Three new malyngamides, J (1), K (2) and L (3), all amides of 7(S)-methoxytetradec-4(E)-enoic acid, were isolated from Curacao collections of Lyngbya majuscula as mentioned in this paper.
59 citations
TL;DR: A Caribbean collection of Lyngbya majuscula which produces the promising antimitotic agent, curacin A, was recollected in 1993 from Curaçao and adapted to laboratory culture, leading to the selection of one reliable strain, ’19L‘, for further studies.
Abstract: A Caribbean collection of Lyngbya majuscula which produces the promising antimitotic agent, curacin A, was recollected in 1993 from Curacao and adapted to laboratory culture. A variety of culture vessel configurations and conditions were examined for their effect on growth and production of curacin A. Using these partially optimized conditions, 29 strains of curacin A producing L. majuscula were evaluated for their production levels of curacin A employing an internal standard GC-MS analytical method. Five strains were more carefully characterized for their growth and curacin A production, and led to our selection of one reliable strain, ’19L‘, for further studies. Growth and curacin A production curves were established for this strain over a 30 day growth period. This directed a scale-up culture of 640 liters of L. majuscula strain 19L in four batches of 160 L each. All four batches grew well and produced significant quantities of curacin A. In tota1, 215.5 g wet weight of L. majuscula tissue were produced which gave an isolated yield of 132.5 mg of curacin A.
27 citations
TL;DR: Pitiamide A, a new chloro-lipid, was isolated from an extract of a mixed assemblage of Lyngbya majuscula and a Microcoleus sp. as discussed by the authors.
26 citations
TL;DR: Fractionation of the lipid extract of the marine cyanobacterium Lyngbya majuscula collected from Curaçao afforded two quinoline alkaloids in low yield, determined as 4,8-dimethyl-6-O-(2'-4'-di-O-methyl-beta-D-xylopyranosyl)-hydroxyquinoli ne and 4,7-dimethyltimethyl- 6-Hydroxyquinoline.
26 citations
TL;DR: A meso -1,4-enediol bis -silyl ether having bicyclo[2.2.1]heptene background has been transformed diastereo and enantioselectively into (−)-malyngolide 1, an antibiotic isolated from the blue-green marine algae, Lyngbya majuscula, via Rh(I)-(R )BINAP-catalyzed asymmetrization and diastereoselective modification of the optically active product thus obtained.
13 citations
Dissertation•
06 Mar 1997
1 citations
01 Jan 1997
TL;DR: This chapter summarizes advances on the discovery of antimutagenic and potential anticancer-type natural products from four species of marine algae, and describes a novel lipid, curacin A, that possesses potent antiproliferative activity through an antimitotic mechanism.
Abstract: This chapter summarizes advances on the discovery of antimutagenic and potential anticancer-type natural products from four species of marine algae. Although terrestrial plants have been broadly surveyed for antimutagenic substances, their marine counterparts have been evaluated on only a preliminary basis. Despite this lack of attention, several notable findings from marine algae have been reported, including our discovery that the tropical green alga Cymopolia barbata makes an assortment of potently antimutagenic terpene-quinones. We have reported on the structure of a novel pigment from the sheaths of diverse blue-green algae (cyanobacteria) that protects the subtending cells from the damaging effects of high ultraviolet irradiance. Subsequently, we found that this pigment possesses powerful antiinflammatory properties in mammalian systems. After study of another tropical blue-green alga, Lyngbya majuscula, we described a novel lipid, curacin A, that possesses potent antiproliferative activity through an antimitotic mechanism. We are currently exploring the mechanism of cytotoxic action displayed by an unique styrylchromone natural product from the marine cryptophyte Chrysophaeum taylori.
1 citations
TL;DR: In this paper, the effects of curacin A on porcine brain tubulin assembly of several synthetic compounds related to the antimitotic agent have been examined, including four stereoisomers of a partial structure at the thiazoline moiety.
Abstract: Curacin A ( 1 ), a novel antimitotic agent, was synthesized in a highly stereo-controlled manner. The four stereoisomers of a partial structure at the thiazoline moiety, 2 were also synthesized to aid in elucidation of the absolute configurations of three chiral centers in curacin A. The effects on porcine brain tubulin assembly of several synthetic compounds related to curacin A were examined.
TL;DR: A meso -1,4-enediol bis -silyl ether having bicyclo[2.2.1]heptene background has been transformed diastereo and enantioselectively into (−)-malyngolide 1, an antibiotic isolated from the blue-green marine algae, Lyngbya majuscula, via Rh(I)-(R )BINAP-catalyzed asymmetrization and diastereoselective modification of the optically active product thus obtained as discussed by the authors.
Abstract: A meso -1,4-enediol bis -silyl ether 2 having bicyclo[2.2.1]heptene background has been transformed diastereo- and enantioselectively into (−)-malyngolide 1 , an antibiotic isolated from the blue-green marine algae, Lyngbya majuscula , via Rh(I)-( R )BINAP-catalyzed asymmetrization and diastereoselective modification of the optically active product thus obtained.
TL;DR: In this paper, a fractionation of the lipid extract of the marine cyanobacterium Lyngbya majuscula collected from Curacao provided two quinoline alkaloids in low yield.
Abstract: Fractionation of the lipid extract of the marine cyanobacterium Lyngbya majuscula collected from Curacao afforded two quinoline alkaloids in low yield. Their structures were determined as 4,8-dimethyl-6-O-(2'-4'-di-O-methyl-beta-D-xylopyranosyl)-hydroxyquinoli ne and 4,8-dimethyl-6-hydroxyquinoline on the basis of spectroscopic analysis, mainly 2D NMR spectroscopy.