Showing papers on "Mucinous tubular and spindle cell carcinoma published in 2007"
TL;DR: Its morphological features as well as a strong preferential expression of proximal tubule markers suggest that this tumor is a type of RCC with proximaltubular differentiation, which appears closely related to or represents a morphological variant of papillary RCC.
113 citations
TL;DR: Ksp-cad is a useful tumor type associated marker for distinguishing chromophobe renal cell carcinoma and renal oncocytoma from the wide range of nonintercalated cell-related adult renal epithelial neoplasms; addition of this marker to a panel comprised of other histologic subtype-associated markers may greatly facilitate histologic subclassification of adult renal anatomy neoplasm.
Abstract: Kidney-specific cadherin (Ksp-cad) is a membrane-associated cell adhesion glycoprotein expressed by the distal nephron tubular cells in its later developmental stages. Chromophobe renal cell carcinoma and renal oncocytoma are reported to be variably positive for Ksp-cad with some studies suggesting
62 citations
TL;DR: A 54‐year‐old woman was hospitalized for flank pain and acute renal failure when imaging studies revealed a 5.2 cm mass in the left kidney that showed an epithelial tumor with round to oval nuclei associated with strands of metachromatic stromal tissue consistent with renal cell carcinoma.
Abstract: A 54-year-old woman was hospitalized for flank pain and acute renal failure when imaging studies revealed a 5.2 cm mass in the left kidney. She was referred for fine needle aspiration of the lesion, which showed an epithelial tumor with round to oval nuclei associated with strands of metachromatic stromal tissue. Cytopathologic diagnosis was consistent with renal cell carcinoma. Subsequent nephrectomy was performed and the surgical pathology specimen showed a mucinous tubular and spindle cell carcinoma of the kidney. The patient has done well post-operatively with 10 months of benign follow-up.
21 citations
Journal Article•
TL;DR: The histological picture was that of classic MTSCC, with alternating small tubules located in a mucin-containing stroma, and spindle cell areas composed of bland, monomorphic cells.
Abstract: Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare, recently described entity. The authors present three new cases. The histological picture was that of classic MTSCC, with alternating small tubules located in a mucin-containing stroma, and spindle cell areas composed of bland, monomorphic cells. On immunohistochemistry, the tumors were positive for epithelial markers, including CK7 and CK18, vimentin, CD15, AMACR, and neuroendocrine markers, such as NSE and CD57. On FISH analysis we found losses on chromosomes 1 and 8, and gains of chromosomes 7 and 17. This is the first report of this rare entity in Polish medical literature.
7 citations