Gladell P. Paner

TL;DR: This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France, where topics brought to consensus included approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns.

TL;DR: Major stage category definitional changes are in Tumor-Node-Metastasis classifications of testicular, penile, and prostate cancer which improve patient stratification for prognosis and management.

TL;DR: An endogenous population of antigen-specific Tregs (termed MJ23 T Regs) were found recurrently enriched in the tumors of mice with oncogene-driven prostate cancer, and were not reactive to a tumor-specific antigen but instead recognized a prostate-associated antigen that was present in tumor-free mice.

TL;DR: Three tumor-intrinsic molecular pathways, β-catenin, PPARγ, and FGFR3, were identified and linked to the exclusion of T cells from urothelial tumors, suggesting potential for sensitivity to checkpoint blockade.

TL;DR: The aggregate literature suggests that chromophobe renal cell carcinoma (RCC) is biologically a tumor of low malignant potential with reported 5-year and 10-year survival rates of 78% to 100% and 80% to 90%, respectively, while a distinct subset of patients progress, and the pT stage of tumor, tumor necrosis, and sarcomatoid change all predict aggressive phenotype of Chromophobe RCC.