Showing papers on "Palmoplantar pustulosis published in 2012"
Journal Article•
TL;DR: An up-to-date overview of current insights into the pathogenesis and different treatment options for SAPHO syndrome is provided and case reports illustrate that TNF blockers can be considered for treatment of refractory SaphO syndrome.
Abstract: Introduction SAPHO is an invalidating syndrome characterised by Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis The low prevalence and heterogeneous presentation often leads to a significant diagnostic delay Here, we provide an up-to-date overview of current insights into the pathogenesis and different treatment options In addition, we describe the effects of anti-TNF treatment in three refractory cases Case reports Patient A is a 25-year-old female with hidradenitis suppurativa, inflammatory back pain and painful joints After diagnosis, anti-TNF treatment was started resulting in clinical improvement Patient B is a 44-year-old woman who presented with acne, palmoplantar pustulosis and anterior chest wall pain Bone scintigraphy showed increased uptake at the anterior chest wall Treatment with bisphosphonates resulted in temporary improvement and subsequent treatment with anti-TNF induced long-term clinical improvement Patient C is a 37-year-old woman with palmoplantar psoriasis, relapsing hidradenitis and inflammatory back pain MRI revealed osteitis of the pubic bone Anti-TNF was started for SAPHO syndrome However, despite a clinical response, our patient discontinued treatment, resulting in rapid deterioration Anti-TNF treatment was re-introduced followed by clinical improvement Conclusion These case reports illustrate, consistent with the current literature, that TNF blockers can be considered for treatment of refractory SAPHO syndrome
37 citations
TL;DR: In this article, the authors reported on two RA patients treated with adalimumab (ADA) who developed palmoplantar pustular despite dermatological treatment and ADA discontinuation.
20 citations
Journal Article•
TL;DR: A case of palmplantar pustular psoriasis in a patient with rheumatoid arthritis treated with etanercept strongly suggests that the development of de novo Psoriasis is a class effect.
Abstract: The development of de novo psoriasis in patients treated with tumor necrosis factor-alpha antagonists is well recognized. The authors hereby report a case of palmplantar pustular psoriasis in a patient with rheumatoid arthritis treated with etanercept. The condition responded to topical steroids but re-occurred upon treating the patient with certolizumab pegol. This strongly suggests that the development of de novo psoriasis is a class effect.
17 citations
TL;DR: The case of a patient who, after administration of infliximab indicated for Crohn’s disease, developed not only skin manifestations but also those of psoriatic arthritis is presented.
Abstract: The induction of psoriasis as a side effect of treatment with TNF-alpha inhibitors is one of a few rare complications of treatment, the pathogenic mechanism of which has not yet been completely clarified. The clinical presentation of these reactions may show the typical characteristics of psoriasis, palmoplantar pustulosis and psoriasiform exanthema; the individual variations of which may combine to give different presentations in individual patients. We present the case of a patient who, after administration of infliximab indicated for Crohn’s disease, developed not only skin manifestations but also those of psoriatic arthritis.
13 citations
TL;DR: This report describes two patients with strikingly similar radiologic presentations of clavicular osteitis in whom the diagnosis was made predominantly on the basis of imaging findings.
9 citations
TL;DR: A patient in whom PV and PPP developed sequentially was reported, and measurements of multiple cytokines and chemokines in the serum suggested the possible involvement of tumour necrosis factor (TNF)-α in the clinical course.
Abstract: © 2012 The Authors. doi: 10.2340/00015555-1158 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Some autoimmune bullous diseases are known to develop in patients with psoriasis. While associations of psoriasis with bullous pemphigoid (BP) and anti-laminin gamma-1 pemphigoid are relatively common (1), pemphigus foliaceus and pemphigus herpetiformis are less frequently associated with psoriasis. In particular, there are only a limited number of reports on pemphigus vulgaris (PV) (2–5). Palmoplantar pustulosis (PPP) is a peculiar and localized form of pustular psoriasis, although its classification is debatable (6). We report here a patient in whom PV and PPP developed sequentially; measurements of multiple cytokines and chemokines in the serum suggested the possible involvement of tumour necrosis factor (TNF)-α in the clinical course.
6 citations
5 citations
TL;DR: The patient was diagnosed with a cranial lesion of synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome and there was a moderate response to treatment with intravenous steroid pulse therapy and subsequent methotrexate.
Abstract: A 50-year-old woman with a history of palmoplantar pustulosis, femur osteomyelitis, and sterno-costo-clavicular hyperostosis presented with a chronic severe left temporal headache that had progressed during the previous year. Her CRP level was elevated. Cranial images showed Gadolinium-enhancement of the left temporal muscle, left parietal bone and dura mater. (99m)Tc-HMDP scintigram showed increased uptake in the left parietal bone, left sterno-costo-clavicular joint, right femoral head and intervertebral joints. Biopsy of the lesion demonstrated 1) proliferation of connective tissue in both perimysium and endomysium of the temporal muscle with mild inflammatory cell infiltration within the interstitium, 2) marked infiltration of granulocytes to the bone marrow of the parietal bone, 3) necrosis and moderate fibrosis in the interstitium with inflammatory cell infiltration in the parietal bone, and 4) moderate fibrosis and slight infiltration of inflammatory cells in the dura mater. The patient was diagnosed with a cranial lesion of synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. There was a moderate response to treatment with intravenous steroid pulse therapy and subsequent methotrexate. In a case of headache accompanied by inflammatory response, palmoplantar pustulosis and joint lesions such as hyperostosis, the possibility of a rare cranial manifestation of SAPHO syndrome should be considered.
5 citations
TL;DR: In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions, and ustekinumab was tested in a few of these patients, indicating potential efficacy.
Abstract: In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.
5 citations
TL;DR: A case of a 49‐year‐old Chinese man with known palmoplantar pustulosis and acrodermatitis continua of Hallopeau is presented which was promptly resolved with methotrexate therapy and achieved successful control of the disease.
Abstract: Eosinophilic pustular folliculitis of Ofuji is a recalcitrant disease typified by non-infective eosinophilic spongiosis involving the infundibular region of the hair follicle. We present a case of a 49-year-old Chinese man with known palmoplantar pustulosis and acrodermatitis continua of Hallopeau which was promptly resolved with methotrexate therapy. He returned with an erythematous papulopustular eruption with coalescence to annular plaques, occurring over the face, chest and back with active palmoplantar pustulation. Histology from skin biopsy of the palmar lesion was in keeping with palmoplantar psoriasis, while biopsy of the facial and truncal lesions revealed florid perifollicular eosinophilic congregation diagnostic of eosinophilic pustular folliculitis of Ofuji. Indomethacin was initiated with partial improvement of lesions with cyclical flares. A trial of narrowband ultraviolet-B phototherapy at a frequency of thrice weekly achieved sustained clearance of both eosinophilic pustular folliculitis and palmoplantar lesions. Indomethacin was tailed down and eventually discontinued with maintenance of narrowband ultraviolet-B therapy; this achieved successful control of the disease.
4 citations
TL;DR: A 32-year-old man presented to the emergency department with 1-month history of continuous chest pain, which was worse with movement and on application of pressure to the anterior chest wall, and a pustule on the sole of his left foot and multiple pustules on his palms.
TL;DR: The diagnosis of Behcet's syndrome is based on clinical criteria and no pathognomonic laboratory findings exist as discussed by the authors, which is a chronic, relapsing, multisystemic, inflammatory disorder.
Abstract: Behcet’s syndrome is a chronic, relapsing, multisystemic, inflammatory disorder. The diagnosis of Behcet’s syndrome is based on clinical criteria and no pathognomonic laboratory findings exist. A diagnosis is made by the presence of recurrent oral ulceration, the hallmark of this disease, plus any two of the following: recurrent genital ulcerations, ocular lesions (anterior or posterior uveitis, cells in vitreous or slit lamp examination, or retinal vasculitis), typical skin lesions, and a positive pathergy (skin hyperreactivity) test. (Published. 11 October 2012) Citation: Libyan J Med 2012, 7 : 19139 - http://dx.doi.org/10.3402/ljm.v7i0.19139
Journal Article•
TL;DR: Fuzheng Jiedu,clearing heat and dampness on palmoplantar pustulosis is a high cure rate, less side effect and other advantages.
Abstract: [Objective] To observe the effect of Fuzhengjiedu,clearing away heat and dampness on palmoplantar pustulosis effect.[Methods] 21 cases of palmoplantar pustulosis patients using self-made soil Fuling soup(tuckahoe,honeysuckle,long-noded pit viper,astragalus root,tuckahoe,grass land,coix seed,angelica,paeonol,tangerine peel,raw licorice root) on the treatment of.2 months of treatment the curative effect.[Results] 13 cases were cured,5 cases,effective in 2 cases,1 cases are invalid,the total efficiency of 85.70%.[Conclusion] Fuzheng Jiedu,clearing heat and dampness on palmoplantar pustulosis is a high cure rate,less side effect and other advantages.
TL;DR: A 24-year-old white woman was referred for investigation of chronic pain and tenderness of the sternocostoclavicular region with minimal soft tissue swelling, and examination did not reveal acne, palmoplantar pustulosis, or psoriasis.
Abstract: Sternocostoclavicular hyperostosis (SCCH), a rare, benign disorder, is frequently associated with skin lesions, but can occur without them. Patients showing only bone lesions initially may later develop cutaneous symptoms.
A 24-year-old white woman was referred for investigation of chronic pain and tenderness of the sternocostoclavicular region with minimal soft tissue swelling. The pain started 1 year before without history of trauma, low back pain, or arthritis. Examination did not reveal acne, palmoplantar pustulosis, or psoriasis. A range of laboratory examinations were …
TL;DR: This paper presents the case of a 50-year-old female patient with palmoplantar pustular changes within the course of eruptive (guttate) psoriasis, based on the patient's history and clinical and histology findings.
Abstract: This paper presents the case of a 50-year-old female patient with palmoplantar pustular changes within the course of eruptive (guttate) psoriasis. The diagnosis was based on the patient's history and clinical and histology findings. The patient was treated with an overnight local administration of betamethasone dipropionate and 3% salicylic acid applied twice daily to the palms and soles with occlusive dressings. The therapy was continued with 25 mg of acitretin daily (in the morning, after breakfast), betamethasone ointment applied twice daily to the palms and soles, and mometasone furoate cream applied in the morning and evening. This treatment led to a significant improvement in the patient's condition.
Journal Article•