Showing papers on "Sodium arsenite published in 1980"
TL;DR: It appears that a variety of treatments, namely, chelating drugs, transition series metals, sulfhydryl reagents, heat shock, and amino acid analogous can induced similar, if not identical, proteins in eukaryotic cells.
338 citations
TL;DR: Two-dimensional gel analysis of in vitro translation products from rabbit reticulocyte lysates primed with mRNA from uninduced and induced cells reveals that the amount of translatable mRNA specific for these proteins is increase by induction.
210 citations
TL;DR: Metal concentrations in the liver and kidney showed that a dose-effect relationship existed at all metal exposure levels; however, the maximal immunosuppressive effect was observed in spite of increasing tissue concentrations of the metal.
113 citations
TL;DR: Dimercapto-1-propane-sulfonic acid and dimercaptosuccinic acid are active orally for the protection of mice against the lethal effects of sodium arsenite and are effective whether given before or after the administration of NaAsO2.
37 citations
TL;DR: A non-lethal dose of sodium arsenite is found to inhibit the formation of single-strand DNA breaks in Escherichia coli WP2 wild-type and WP6 polA strains after UV irradiation, and post-replication repair in WP2 uvrA strainsafter UV irradation is also inhibited.
Abstract: A non-lethal dose of sodium arsenite is found to inhibit the formation of single-strand DNA breaks in Escherichia coli WP2 wild-type and WP6 polA strains after UV irradiation. Inhibition of single-strand breakage follows a dose-dependent relationship with respect to increasing sodium arsenite concentration. ATP level in WP2 cells is decreased in the presence of sodium arasenite and therefore the inhibition of DNA break formation may be mediated through lowered ATP levels in the irradiated cells. In the presence of a non-lethal dose of sodium aresenite, post-replication repair in WP2 uvrA strains after UV irradation is also inhibited.
27 citations
TL;DR: The findings of this study indicate that arsenical disturbance of in vivo carbohydrate metabolism is a complex phenomenon which involves a number of organ systems and their functional interrelationships.
27 citations
TL;DR: In this article, cultures were treated with As(lll) or As(V) in the form of sodium arsenite (NaAsO2) or sodium arsenate (Na2HAsO4), respectively, to determine whether low levels of arsenic affect cell proliferation and chromatin constituents.
Abstract: Because of the causal association between arsenic and cancer in humans, studies were initiated to determine whether low levels of arsenic affect cell proliferation and chromatin constituents. Cultured CHO cells were treated with As(lll) or As(V) in the form of sodium arsenite (NaAsO2) or sodium arsenate (Na2HAsO4), respectively. Arsenite was 10 times more toxic than arsenate, 50 μM arsenite causing irreversible inhibition of culture growth. At lower concentrations, 10 μM NaAsOi induced culture growth kinetics that were radiomimetic‐that is, caused a cell division delay period followed by spontaneous recovery of cell division in the continued presence of the arsenite. During this division delay, histone HI phos‐phorylation was reduced to 40% of the control level. It recovered to the control level just before recovery of cell division. Histone H2A phosphorylation was stimulated in the middle of the delay period, followed by stimulation of H3 phosphorylation just before recovery of cell division. A TP pool l...
16 citations