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A. J. Rush
Researcher at National University of Singapore
Publications - 20
Citations - 990
A. J. Rush is an academic researcher from National University of Singapore. The author has contributed to research in topics: Major depressive disorder & Depression (differential diagnoses). The author has an hindex of 14, co-authored 20 publications receiving 824 citations. Previous affiliations of A. J. Rush include University of Texas Southwestern Medical Center & Durham University.
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Journal ArticleDOI
Residual Symptoms in Depressed Outpatients Who Respond by 50% But Do Not Remit to Antidepressant Medication
Shawn M. McClintock,Mustafa M. Husain,Stephen R. Wisniewski,Andrew A. Nierenberg,Jonathan W. Stewart,Madhukar H. Trivedi,Ian A. Cook,David W. Morris,Diane Warden,A. J. Rush +9 more
TL;DR: Depressed outpatients who respond by 50% without remitting to citalopram treatment have a broad range of residual symptoms, suggesting individualized treatments are warranted to specifically address each patient's residual depressive symptoms.
Journal ArticleDOI
Improving the prediction of treatment response in depression: integration of clinical, cognitive, psychophysiological, neuroimaging, and genetic measures.
TL;DR: It is proposed that a focus on standardized testing methodologies across multiple testing modalities and their integration will be crucial for translation of research findings into clinical practice.
Journal ArticleDOI
CYP2C19 variation and citalopram response.
David A. Mrazek,Joanna M. Biernacka,Dennis J. O'Kane,John L. Black,Julie M. Cunningham,Maureen S. Drews,Karen Snyder,Susanna R. Stevens,A. J. Rush,Richard M. Weinshilboum +9 more
TL;DR: Variations in CYP2C19 were associated with tolerance and remission in a large sample of White non-Hispanic patients treated with citalopram, despite several limitations including the lack of serum drug levels.
Journal ArticleDOI
Increased hippocampal tail volume predicts depression status and remission to anti-depressant medications in major depression.
Jerome Joseph Maller,Jerome Joseph Maller,Kathryn M. Broadhouse,A. J. Rush,E Gordon,Stephen H. Koslow,Stuart M. Grieve +6 more
TL;DR: Larger hippocampal tail volume was positively related to clinical remission, independent of total hippocampal volume, total brain volume and age, and convergent evidence of the importance of the hippocampus in the development or treatment of MDD is provided.
Journal ArticleDOI
Is prior course of illness relevant to acute or longer-term outcomes in depressed out-patients? A STAR*D report.
A. J. Rush,S. R. Wisniewski,Sidney Zisook,Maurizio Fava,Sharon C. Sung,Charlotte L. Haley,H. N. Chan,William S. Gilmer,Diane Warden,Andrew A. Nierenberg,Goundappa K. Balasubramani,Bradley N. Gaynes,Madhukar H. Trivedi,Steve D. Hollon +13 more
TL;DR: Recurrent MDD is the norm for out-patients, of whom 15% also have a chronic index episode and chronic and recurrent course may be useful in predicting acute and long-term MDD treatment outcomes.