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A. L. Lafontaine
Researcher at University of Calgary
Publications - 5
Citations - 427
A. L. Lafontaine is an academic researcher from University of Calgary. The author has contributed to research in topics: Age of onset & Chromosome 21. The author has an hindex of 5, co-authored 5 publications receiving 410 citations.
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Journal ArticleDOI
Canadian Guidelines on Parkinson's Disease.
David Grimes,Joyce Gordon,Barbara Snelgrove,Ivy Lim-Carter,Edward A. Fon,W.R. Wayne Martin,Marguerite Wieler,Oksana Suchowersky,Alex Rajput,A. L. Lafontaine,Jon Stoessl,Elena Moro,Kerrie Schoffer,Janis M. Miyasaki,Doug Hobson,Minoo Mahmoudi,Susan H. Fox,Ronald B. Postuma,Hrishikesh Kumar,Mandar Jog +19 more
Journal ArticleDOI
PARK3 Influences Age at Onset in Parkinson Disease: A Genome Scan in the GenePD Study
Anita L. DeStefano,Mark F. Lew,Lawrence I. Golbe,Margery H. Mark,Alice M. Lazzarini,Mark Guttman,Erwin B. Montgomery,Cheryl H. Waters,Carlos Singer,Ray L. Watts,Lillian J. Currie,G. Frederick Wooten,Nancy E. Maher,Jemma B. Wilk,Kristin M. Sullivan,Karen M. Slater,Marie Saint-Hilaire,Robert G. Feldman,Oksana Suchowersky,A. L. Lafontaine,N. Labelle,John H. Growdon,Peter Vieregge,Peter P. Pramstaller,Christine Klein,Jean P. Hubble,Carson Reider,Mark Stacy,Marcy E. MacDonald,James F. Gusella,Richard H. Myers +30 more
TL;DR: A genomewide linkage analysis using variance-component methodology to identify genes influencing age at onset of PD in a population of affected relatives (mainly affected sibling pairs) participating in the GenePD study showed suggestive evidence of linkage.
Journal ArticleDOI
Genome-wide scan for Parkinson's disease: the GenePD Study.
Anita L. DeStefano,Lawrence I. Golbe,Margery H. Mark,Alice Lazzarini,Nancy E. Maher,Marie Saint-Hilaire,Robert G. Feldman,Mark Guttman,Ray L. Watts,Oksana Suchowersky,A. L. Lafontaine,N. Labelle,Mark F. Lew,Cheryl H. Waters,John H. Growdon,Carlos Singer,Lillian J. Currie,G. F. Wooten,Peter Vieregge,Peter P. Pramstaller,Christine Klein,Jean P. Hubble,Mark Stacy,Erwin B. Montgomery,Marcy E. MacDonald,James F. Gusella,Richard H. Myers +26 more
TL;DR: A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs reported suggests no strong evidence for linkage was found for any locus, but results may be of value in comparison with similar studies by others.
Journal ArticleDOI
Epidemiologic study of 203 sibling pairs with Parkinson’s disease The GenePD study
Nancy E. Maher,Lawrence I. Golbe,Alice Lazzarini,Margery H. Mark,Lillian J. Currie,G. F. Wooten,Marie Saint-Hilaire,Jemma B. Wilk,Jeannine S. Volcjak,J. E. Maher,Robert G. Feldman,Mark Guttman,Mark F. Lew,S. Schuman,Oksana Suchowersky,A. L. Lafontaine,N. Labelle,Peter Vieregge,Peter P. Pramstaller,Christine Klein,Jean P. Hubble,Carson Reider,John H. Growdon,Ray L. Watts,Erwin B. Montgomery,Kenneth B. Baker,Carlos Singer,Mark Stacy,Richard H. Myers +28 more
TL;DR: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD.
Journal ArticleDOI
A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease.
Ira Shoulson,J. B. Penney,Michael P. McDermott,Steven R. Schwid,Elise Kayson,Chase T,Stanley Fahn,Greenamyre Jt,Lang A,Andrew Siderowf,Nancy Pearson,Madaline B. Harrison,Rost E,Amy Colcher,Mary Lloyd,Matthews M,Rajesh Pahwa,McGuire D,Mark F. Lew,S. Schuman,Kenneth Marek,Broshjeit S,Stewart A. Factor,Diane Brown,Andrew Feigin,Jennifer Mazurkiewicz,Blair Ford,Danna Jennings,Dilllon S,Cynthia L. Comella,Lucia M. Blasucci,Kimberly Janko,Lawrence N. Shulman,Wiener W,Bateman-Rodriguez D,Carrion A,Oksana Suchowersky,A. L. Lafontaine,Pantella C,Eric Siemers,Joann Belden,Davies R,Margaret C. Lannon,David Grimes,Peggy Gray,W.R. Wayne Martin,Kennedy L,Charles H. Adler,Stephanie Newman,John P. Hammerstad,C. Stone,Peter A LeWitt,Bardram K,Mistura K,Janis M. Miyasaki,Johnston L,Cha Jh,Marsha Tennis,Panniset M,Jean Hall,James W. Tetrud,Jeffrey Friedlander,Robert A. Hauser,Lisa Gauger,Robert L. Rodnitzky,Deleo A,Judith Dobson,Lauren Seeberger,Colleen Dingmann,Daniel Tarsy,Paula D. Ryan,Lawrence Elmer,Ruzicka D,Mark Stacy,M. Brewer,Locke B,Baker D,Cindy Casaceli,Denni Day,Florack M,Karen Hodgeman,Nirupama Laroia,Nobel R,Constance Orme,Rexo L,Rothenburgh K,Sulimowicz K,Arthur Watts,Wratni E,Pierre N. Tariot,Christopher Cox,Leventhal C,Alderfer,Craun Am,Frey J,McCree L,McDermott J,Cooper J,Holdich T,Read B +99 more
TL;DR: Remacemide is a safe and tolerable adjunct to dopaminergic therapy for patients with PD and motor fluctuations and the observed improvement is consistent with studies of non-human primates with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced parkinsonian signs and symptoms.