P
Peter Vieregge
Researcher at University of Lübeck
Publications - 112
Citations - 9524
Peter Vieregge is an academic researcher from University of Lübeck. The author has contributed to research in topics: Parkinsonism & Parkin. The author has an hindex of 46, co-authored 112 publications receiving 9057 citations. Previous affiliations of Peter Vieregge include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich,Alexander Zimprich,Saskia Biskup,Petra Leitner,Peter Lichtner,Matthew J. Farrer,Sarah Lincoln,Jennifer M. Kachergus,Mary M. Hulihan,Ryan J. Uitti,Donald B. Calne,A. Jon Stoessl,Ronald F. Pfeiffer,Nadja Patenge,Iria Carballo Carbajal,Peter Vieregge,Friedrich Asmus,Bertram Müller-Myhsok,Dennis W. Dickson,Thomas Meitinger,Tim M. Strom,Zbigniew K. Wszolek,Thomas Gasser +22 more
TL;DR: High-resolution recombination mapping and candidate gene sequencing in 46 families found six disease-segregating mutations in a gene encoding a large, multifunctional protein, LRRK2 (leucine-rich repeat kinase 2), which may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism.
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A susceptibility locus for Parkinson's disease maps to chromosome 2p13
Thomas Gasser,Bertram Müller-Myhsok,Zbigniew K. Wszolek,Ralph Oehlmann,Donald B. Calne,Vincenzo Bonifati,Benjamin Bereznai,Edito Fabrizio,Peter Vieregge,Rolf D. Horstmann +9 more
TL;DR: A different genetic locus that appears to be involved in the development of parkinsonism closely resembling sporadic PD is described including a similar mean age of onset (59 years in the families, 59.7 years in sporadic PD; ref. 12).
Journal ArticleDOI
Possible environmental, occupational, and other etiologic factors for Parkinson's disease: A case‐control study in Germany
Andreas Seidler,Wiebke Hellenbrand,B.-P. Robra,Peter Vieregge,P. Nischan,J. Joerg,Wolfgang H. Oertel,G. Ulm,E. Schneider +8 more
TL;DR: A role for environmental and genetic factors in the etiology of PD is supported by a case-control study investigating possible etiologic relevance to Parkinson's disease of rural factors such as farming activity, pesticide exposures, well-water drinking, and animal contacts.
Journal ArticleDOI
MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.
Kristien Verhoeven,Kristl Claeys,Stephan Züchner,Stephan Züchner,J. Michael Schröder,Joachim Weis,Chantal Ceuterick,Albena Jordanova,Eva Nelis,Els De Vriendt,Matthias Van Hul,Pavel Seeman,Radim Mazanec,Gulam Mustafa Saifi,Kinga Szigeti,Pedro Mancias,Ian J. Butler,Andrzej Kochański,Barbara Ryniewicz,Jan De Bleecker,Peter Van den Bergh,Christine Verellen,Rudy Van Coster,Nathalie Goemans,Michaela Auer-Grumbach,Wim Robberecht,Vedrana Milic Rasic,Yoram Nevo,I. Tournev,Velina Guergueltcheva,Filip Roelens,Peter Vieregge,Paolo Vinci,María Teresa García Moreno,H.-J. Christen,Michael E. Shy,James R. Lupski,Jeffery M. Vance,Peter De Jonghe,Vincent Timmerman +39 more
TL;DR: Electrophysiological data showed in the majority of patients normal to slightly reduced nerve conduction velocities with often severely reduced amplitudes of the compound motor and sensory nerve action potentials, whereas a smaller group experienced a later onset and milder disease course.
Journal ArticleDOI
Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial Parkinsonism associated with mutations in the Parkin gene
Ruediger Hilker,Christine Klein,Mehran Ghaemi,Bernhard Kis,Tim Strotmann,Laurie J. Ozelius,Olaf Lenz,Peter Vieregge,Karl Herholz,Wolf-Dieter Heiss,Wolf-Dieter Heiss,Peter P. Pramstaller +11 more
TL;DR: PET data provide evidence that parkinsonism in this family is associated with presynaptic dopaminergic dysfunction similar to idiopathic Parkinson's disease pathophysiology, along with alterations at the postsynaptic D2 receptor level.