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W.R. Wayne Martin
Researcher at University of Alberta
Publications - 144
Citations - 12134
W.R. Wayne Martin is an academic researcher from University of Alberta. The author has contributed to research in topics: Parkinson's disease & Positron emission tomography. The author has an hindex of 55, co-authored 141 publications receiving 11421 citations. Previous affiliations of W.R. Wayne Martin include University of California, Los Angeles & Cross Cancer Institute.
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Journal Article
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
TL;DR: The well-known tissue autoradiographic technique for the measurement of regional cerebral blood flow (CBF) is adapted using positron emission tomography (PET) and intravenously administered oxygen-15-labeled water and the correlation between CBF measured with PET and the true CBF for the same cerebral hemisphere was excellent.
Journal ArticleDOI
Diffusion tensor imaging of white matter tract evolution over the lifespan
Catherine Lebel,Michael S. Gee,Richard Camicioli,Marguerite Wieler,W.R. Wayne Martin,Christian Beaulieu +5 more
TL;DR: Clear age-related microstructural changes throughout the brain white matter are demonstrated, and normative data is provided that will be useful for studying white matter development in a variety of diseases and abnormal conditions.
Journal Article
Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography
TL;DR: The technique was implemented on five normal human subjects in whom the global CMRO2 was 2.93 +/- 0.37 (s.d.) ml/min X 100 g and validated in baboons by comparing the PET-measured E with E measured using an intracarotid injection of [O-15]O2.
Journal ArticleDOI
Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group.
Douglas E. Hobson,Anthony E. Lang,W.R. Wayne Martin,Ajmal Razmy,Jean Rivest,Jonathan Fleming +5 more
TL;DR: Excessive daytime sleepiness is common even in patients with PD who are independent and do not have dementia, and its specificity can be increased by use of the Inappropriate Sleep Composite Score.
Journal ArticleDOI
A controlled trial of rasagiline in early Parkinson disease: The tempo study
Andrew Siderowf,Matthew B. Stern,Ira Shoulson,Karl Kieburtz,David Oakes,Denni Day,Aileen Shinaman,Sandra Plumb,Stanley Fahn,Karen Blindauer,Mark F. Lew,Howard I. Hurtig,Mary Lloyd,Robert A. Hauser,Lisa Gauger,Lawrence I. Golbe,Joanne Wojcieszek,Joann Belden,Andrew Feigin,Mary Lou Klimek,Barbara Shannon,William G. Ondo,Christine Hunter,Vincent Calabrese,Paul Atchison,Cathy W. Allen,Frederick J. Marshall,Debra Berry,Irenita Gardiner,Janis M. Miyasaki,Luisa Del Rizzo,Tilak Mendis,Neila Mendis,Peggy Gray,Jean P. Hubble,Karen Betcher,Rajesh Pahwa,Eric Molho,Diane Brown,Lisa M. Shulman,Ali H. Rajput,Marianne Ewanishin,Mark Stacy,Kelli Williamson,John M. Bertoni,Carolyn Peterson,Paul J. Tuite,Brenda Ebbitt,Kathleen M. Shannon,Jean A. Jaglin,Caroline M. Tanner,Kenneth Marek,Karen Stavris,Michael J. Aminoff,Mariann DiMinno,Glenna A. Dowling,Un Jung Kang,Judy Richman,Kapil D. Sethi,W.R. Wayne Martin,Pamela King,Germaine McInnes,Charles H. Adler,Peter A. LeWitt,Maryan DeAngelis,Myrna Schear,Mark Forrest Gordon,Roberta Winnick,Robert G. Feldman,Cathi A. Thomas,Kelly M. Conn,Alicia Brocht,Chris Chadwick,Jeannette Connolly,Susan Daigneault,Shirley Eberly,Janice Bausch,Lee Josephson,Rosemary Oliva,Steven R. Schwid,Anthony E. Lang,Christopher Cox,Carrie Irvine,John G. Nutt,William B. White,Sheila Oren,Ruth Levy,Eli Eyal,David Ladkani,Wayne Houck +89 more
TL;DR: Rasagiline is effective as monotherapy for patients with early PD and the 2 dosages in this trial were both effective relative to placebo.