A
A.M. Scofield
Researcher at University of London
Publications - 18
Citations - 684
A.M. Scofield is an academic researcher from University of London. The author has contributed to research in topics: Castanospermine & Hydroxymethyl. The author has an hindex of 13, co-authored 18 publications receiving 674 citations. Previous affiliations of A.M. Scofield include Royal Botanic Gardens.
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Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids
TL;DR: Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases and the indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.
Journal ArticleDOI
Isolation from and x-ray crystal structure of alexine, (1r,2r,3r,7s,8s)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2r,3r,4r,5s,6s)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], a unique pyrrolizidine alkaloid
Robert J. Nash,Linda E. Fellows,Janet V. Dring,George W. J. Fleet,Andrew E. Derome,T.A Hamor,A.M. Scofield,David J. Watkin +7 more
TL;DR: The isolation from Alexa leiopetala and identification by X-ray crystal structure analysis of (1R,2R,3R,4R,5S,6S)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], a unique pyrrolizidine alkaloid, is described in this paper.
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α-Homonojirimycin [2,6-dideoxy-2,6-imino-d-glycero-l-gulo-heptitol] from omphalea diandra L.: isolation and glucosidase inhibtion
Geoffrey C. Kite,Linda E. Fellows,George W. J. Fleet,Paul S. Liu,A.M. Scofield,Neal Griffith Smith +5 more
TL;DR: The isolation of α-homonojirimycin from Omphalea diandra is described and it is shown that this compound is an inhibitor of several α-glucosidases.
Journal ArticleDOI
Two alexines [3-hydroxymethyl-1,2,7-trihydroxypyrrolizidines] from Castanospermum australe
Robert J. Nash,Linda E. Fellows,Janet V. Dring,George W. J. Fleet,George W. J. Fleet,Aarti Girdhar,Nigel Ramsden,Nigel Ramsden,Josephine M. Peach,Josephine M. Peach,Mervyn P. Hegarty,Mervyn P. Hegarty,A.M. Scofield,A.M. Scofield +13 more
TL;DR: Two new alexines have been isolated from Castanospermum australe and the structure of 1 7a-diepialexine was firmly established by X-ray crystallographic analysis of the corresponding 1,7-isopropylidene derivative as discussed by the authors.
Journal ArticleDOI
Isolation from and x-ray crystal structure of 3,8-diepialexine, (1r,2r,3s,7s,8r)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2s,3r,4r,5s,6r)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol]
Robert J. Nash,Linda E. Fellows,A. C. Plant,George W. J. Fleet,Andrew E. Derome,Peter D. Baird,M.P. Hegarty,A.M. Scofield +7 more
TL;DR: In this paper, the isolation from Castanospermum australe and identification by X-ray crystal structure analysis of (1R,2R,3S,7S,8R)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2S,3R,4R,5S,6R)-2-hydronymethyl]-1-azabicyclo[3.3.0]octan-3,4,6-triol], the second example of a p