Journal ArticleDOI
Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids
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TLDR
Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases and the indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.About:
This article is published in Life Sciences.The article was published on 1986-08-18. It has received 132 citations till now. The article focuses on the topics: Castanospermine & Disaccharidase.read more
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Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.
TL;DR: Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms, and only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.
Journal ArticleDOI
Inhibition of HIV replication by amino-sugar derivatives.
George W. J. Fleet,Abraham Karpas,Raymond A. Dwek,Linda E. Fellows,A.S. Tyms,Sigthor Petursson,Sung K. Namgoong,Nigel Ramsden,P.W. Smith,Jong Chan Son,Francis Xavier Wilson,Witty David R,Gary S. Jacob,Gary S. Jacob,Thomas W. Rademacher +14 more
TL;DR: The relative efficacy of a spectrum of amino‐sugar derivatives as inhibition of HIV cytopathicity is reported, and several α‐glucosidase inhibitors and α‐fucosinase inhibitors were found to be active at concentrations which were non‐cytotoxic.
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Aminosugar derivatives as potential anti-human immunodeficiency virus agents
Abraham Karpas,George W. J. Fleet,Raymond A. Dwek,Sigthor Petursson,Sung K. Namgoong,Nigel Ramsden,Gary S. Jacob,Thomas W. Rademacher +7 more
TL;DR: A method to score in parallel both the degree of antiviral activity and the effect on cell division of aminosugar derivatives suggests that replication is associated with cytolysis, which has important implications in the chemotherapy of AIDS.
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Synthesis and Biological Activity of Natural Aminocyclopentitol Glycosidase Inhibitors: Mannostatins, Trehazolin, Allosamidins, and Their Analogues.
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N-containing sugars from Morus alba and their glycosidase inhibitory activities.
TL;DR: It has recently been found that the polyhydroxy-nor-tropane alkaloids possess potent glycosidase inhibitory activities.
References
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Journal ArticleDOI
Determination of protein: A modification of the lowry method that gives a linear photometric response
TL;DR: Under the new conditions there is direct proportionality between absorbance at 650 nm and weight of protein within the range 15–110 μg.
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Assay of intestinal disaccharidases.
TL;DR: A modified and updated description of the author's method for the assay of intestinal disaccharidase activity is presented, and the glucose liberated is measured with a glucose oxidase reagent.
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Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
TL;DR: In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.
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Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe
Liza D. Hohenschutz,E.Arthur Bell,Phillip J. Jewess,David P. Leworthy,Robert J. Pryce,Edward Arnold,Jon Clardy +6 more
TL;DR: A new type of higher plant alkaloid, 1,6,7,8-tetrahydroxyoctahydroindolizine, designated castanospermine, has been isolated from the toxic seeds of the Australian legume Castanospermum australe.
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Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides
TL;DR: In vivo dMM inhibits the equivalent of the mannosidase IA/B activities and blocks conversion of high-mannose to complex oligosaccharides, which could prove to be a powerful way to manipulate carbohydrate structure in vivo.