A.M. Scofield

TL;DR: Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases and the indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

TL;DR: The isolation from Alexa leiopetala and identification by X-ray crystal structure analysis of (1R,2R,3R,4R,5S,6S)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], a unique pyrrolizidine alkaloid, is described in this paper.

TL;DR: The isolation of α-homonojirimycin from Omphalea diandra is described and it is shown that this compound is an inhibitor of several α-glucosidases.

TL;DR: Two new alexines have been isolated from Castanospermum australe and the structure of 1 7a-diepialexine was firmly established by X-ray crystallographic analysis of the corresponding 1,7-isopropylidene derivative as discussed by the authors.

TL;DR: In this paper, the isolation from Castanospermum australe and identification by X-ray crystal structure analysis of (1R,2R,3S,7S,8R)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2S,3R,4R,5S,6R)-2-hydronymethyl]-1-azabicyclo[3.3.0]octan-3,4,6-triol], the second example of a p