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A. Suter
Researcher at University of Göttingen
Publications - 5
Citations - 1120
A. Suter is an academic researcher from University of Göttingen. The author has contributed to research in topics: Lysosome & Osteopontin. The author has an hindex of 4, co-authored 5 publications receiving 1056 citations.
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Journal ArticleDOI
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Yoshitaka Tanaka,Yoshitaka Tanaka,Gundula Guhde,A. Suter,Eeva-Liisa Eskelinen,Eeva-Liisa Eskelinen,Eeva-Liisa Eskelinen,Dieter Hartmann,Renate Lüllmann-Rauch,Paul M.L. Janssen,Judith Blanz,Kurt von Figura,Paul Saftig +12 more
TL;DR: Findings indicate that LAMP-2 is critical for autophagy, and this theory is further substantiated by the finding that human Lamp-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes.
Book ChapterDOI
Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice.
Paul Saftig,E Hunziker,Vincent Everts,Siana Jones,Alan Boyde,O. Wehmeyer,A. Suter,K von Figura +7 more
TL;DR: The phenotype of cathepsin K knockout mice underlines the importance of this proteinase in bone remodelling and is in contrast to other forms of osteopetrosis, which are due to disrupted osteoclastogenesis.
Journal ArticleDOI
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice
A. Suter,Vincent Everts,Alan Boyde,Sheila J. Jones,Renate Lüllmann-Rauch,Dieter Hartmann,Alison R. Hayman,Timothy M. Cox,Martin J. Evans,T. Meister,K von Figura,Paul Saftig +11 more
TL;DR: It is concluded that for several substrates LAP and Acp5 can substitute for each other and that these acid phosphatases are essential for processing of non-collagenous proteins, including osteopontin, by osteoclasts.
Journal ArticleDOI
Biosynthesis of phosphatidylcholine from a phosphocholine precursor pool derived from the late endosomal/lysosomal degradation of sphingomyelin.
Suzanne M. Jansen,Johanna E. M. Groener,Wim Bax,A. Suter,Paul Saftig,Pentti Somerharju,Ben J. H. M. Poorthuis +6 more
TL;DR: Evidence is provided that, in fibroblasts, phosphocholine derived from sphingomyelin is transported out of the lysosome and subsequently incorporated into phosphatidylcholine without prior hydrolysis of phosphicholine to choline.