Aaron Yun Chen

TL;DR: It is reported that in human breast cancer cells 17β-oestradiol (E2)-bound oestrogen receptor α (ER-α) causes a global increase in eRNA transcription on enhancers adjacent to E2-upregulated coding genes, indicating that eRNAs are likely to have important functions in many regulated programs of gene transcription.

TL;DR: Important information about the genus Bocavirus is revealed that may eventually help to clone the human bocav virus and study its pathogenesis.

TL;DR: The sequence of a full-length HBoV1 genome is obtained using viral DNA extracted from a nasopharyngeal aspirate of an infected patient, cloned the full- lengths, and DNA replication, encapsidation of the ssDNA genome, and release of the H BoV1 virions from human embryonic kidney 293 cells are demonstrated.

TL;DR: A quantitative transcription profile of human bocavirus type 1 was generated by transfecting a nearly full-length clone in human lung epithelial A549 cells as well as in a replication competent system in 293 cells and showed that, unlike human parvovirus B19 infection, expression of the HBoV1 proteins only does not induce cell cycle arrest and apoptosis of A549 Cells.

TL;DR: Both condensin complexes exhibit an unexpected, dramatic estrogen-induced recruitment to estrogen receptor α (ER-α)-bound eRNA(+) active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-α via its DNA-binding domain (DBD).