W
Wen Liu
Researcher at University of California, San Diego
Publications - 21
Citations - 3517
Wen Liu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Retinoid X receptor & Regulation of gene expression. The author has an hindex of 15, co-authored 21 publications receiving 3216 citations. Previous affiliations of Wen Liu include Howard Hughes Medical Institute & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
Dong Wang,Ivan Garcia-Bassets,Christopher Benner,Wenbo Li,Xue Su,Yiming Zhou,Jinsong Qiu,Wen Liu,Minna U. Kaikkonen,Kenneth A. Ohgi,Christopher K. Glass,Michael G. Rosenfeld,Xiang-Dong Fu +12 more
TL;DR: Evidence is presented that cell-lineage-specific factors, such as FoxA1, can simultaneously facilitate and restrict key regulated transcription factors, exemplified by the androgen receptor (AR), to act on structurally and functionally distinct classes of enhancer.
Journal ArticleDOI
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
Bingzhen Lin,Siva Kumar Kolluri,Feng Lin,Wen Liu,Young-Hoon Han,Xihua Cao,Marcia I. Dawson,John C. Reed,Xiao-kun Zhang +8 more
TL;DR: It is shown that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis induced by many antineoplastic agents, and can manifest opposing phenotypes, induced by interactions with proteins such as Nur77, suggesting novel strategies for regulating apoptosis in cancer and other diseases.
Journal ArticleDOI
ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs
Liuqing Yang,Chunru Lin,Wen Liu,Jie Zhang,Kenneth A. Ohgi,Jonathan D. Grinstein,Pieter C. Dorrestein,Michael G. Rosenfeld +7 more
TL;DR: Observations delineate a molecular pathway linking the actions of subnuclear structure-specific ncRNAs and nonhistone protein methylation to relocation of transcription units in the three-dimensional space of the nucleus, thus achieving coordinated gene expression programs.
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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Wen Liu,Bogdan Tanasa,Bogdan Tanasa,Oksana V. Tyurina,Tian Yuan Zhou,Reto Gassmann,Wei-Ting Liu,Kenneth A. Ohgi,Christopher Benner,Ivan Garcia-Bassets,Aneel K. Aggarwal,Arshad Desai,Pieter C. Dorrestein,Christopher K. Glass,Michael G. Rosenfeld +14 more
TL;DR: The identification and characterization of an H4K20me1 demethylase, PHF8, has revealed an intimate link between this enzyme and two distinct events in cell cycle progression.
Journal ArticleDOI
The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus
Zhi-Hong Zhou,Jinsong Qiu,Wen Liu,Yu Zhou,Ryan M. Plocinik,Hairi Li,Qidong Hu,Gourisanker Ghosh,Joseph A. Adams,Michael G. Rosenfeld,Xiang-Dong Fu +10 more
TL;DR: In this article, a massive reprogramming of alternative splicing in response to EGF signaling is reported, which reveals a major signal transduction pathway for regulated splicing and place SRPKs in a central position in the pathway, consistent with their reputed roles in a large number of human cancers.