Aarooran Sivakumaran Durairaj

TL;DR: This article showed that myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation.

TL;DR: In this paper, an inside-out redox signal of mitochondria was reported, and it was shown that blocking the MIC60-Miro interaction or reducing either protein, genetically or pharmacologically, extends lifespan and health-span of healthy fruit flies.

TL;DR: It is shown that in vivo blockade of glycogenolysis is sufficient to rescue survival in peritonitis, hepatitis, and sepsis and holds implications for the treatment of acute inflammatory disorders at large.

TL;DR: In this article , a linear pathway linking several potential PD risk genes and elements to one biological pathway was proposed. But, the pathway was not tested on human blood cells, and the results showed that rare, non-synonymous variants in this iron-calcium-Miro axis influenced PD risk.

TL;DR: This issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglia quiescence after peripheral endotoxin challenge.