Y
Yuki Sugiura
Researcher at Keio University
Publications - 183
Citations - 7176
Yuki Sugiura is an academic researcher from Keio University. The author has contributed to research in topics: Mass spectrometry imaging & Mass spectrometry. The author has an hindex of 45, co-authored 162 publications receiving 5229 citations. Previous affiliations of Yuki Sugiura include Tokyo Institute of Technology & Mitsubishi.
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Journal ArticleDOI
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Takeshi Tanoue,Satoru Morita,Damian R. Plichta,Ashwin N. Skelly,Wataru Suda,Wataru Suda,Yuki Sugiura,Seiko Narushima,Hera Vlamakis,Iori Motoo,Kayoko Sugita,Atsushi Shiota,Kozue Takeshita,Keiko Yasuma-Mitobe,Dieter Riethmacher,Tsuneyasu Kaisho,Jason M. Norman,Daniel Mucida,Makoto Suematsu,Tomonori Yaguchi,Vanni Bucci,Takashi Inoue,Yutaka Kawakami,Bernat Olle,Bruce L. Roberts,Masahira Hattori,Masahira Hattori,Ramnik J. Xavier,Ramnik J. Xavier,Koji Atarashi,Kenya Honda +30 more
TL;DR: A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models.
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HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Hiroaki Semba,Norihiko Takeda,Takayuki Isagawa,Yuki Sugiura,Kurara Honda,Masaki Wake,Hidenobu Miyazawa,Yoshifumi Yamaguchi,Masayuki Miura,Masayuki Miura,Dana M. R. Jenkins,Hyunsung Choi,Jung Whan Kim,Masataka Asagiri,Andrew S. Cowburn,Hajime Abe,Katsura Soma,Katsuhiro Koyama,Manami Katoh,Keimon Sayama,Nobuhito Goda,Randall S. Johnson,Ichiro Manabe,Ryozo Nagai,Issei Komuro +24 more
TL;DR: It is shown that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming.
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Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas,Amira Latif-Hernandez,Melanie R. McReynolds,Aarooran Sivakumaran Durairaj,Qian Wang,Amanda J. Rubin,Amit Joshi,Joy Q He,Esha Gauba,Ling Liu,Congcong Wang,Miles H. Linde,Yuki Sugiura,Peter K. Moon,Ravi Majeti,Makoto Suematsu,Daria Mochly-Rosen,Irving L. Weissman,Frank M. Longo,Joshua D. Rabinowitz,Katrin I. Andreasson +20 more
TL;DR: This article showed that myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation.
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Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry.
Yuki Sugiura,Yoshiyuki Konishi,Yoshiyuki Konishi,Nobuhiro Zaima,Nobuhiro Zaima,Shigeki Kajihara,Hiroki Nakanishi,Ryo Taguchi,Mitsutoshi Setou,Mitsutoshi Setou +9 more
TL;DR: The results showed that PUFA-containing phosphatidylcholines (PCs) were distributed in a cell-selective manner: arachidonic acid- and docosahexaenoic acid-containing PCs were seen in the hippocampal neurons and cerebellar Purkinje cells, respectively.
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MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis
Shuichi Shimma,Yuki Sugiura,Yuki Sugiura,Yuki Sugiura,Takahiro Hayasaka,Yutaka Hoshikawa,Tetsuo Noda,Mitsutoshi Setou +7 more
TL;DR: The results of matrix-assisted laser desorption/ionization (MALDI) imaging and direct molecular identification using tandem mass spectrometry (MS/MS) in colon cancer liver metastasis show the feasibility of MALDI imaging as a tool for the analysis of pathological specimens.