J
Joy Q He
Researcher at Stanford University
Publications - 9
Citations - 447
Joy Q He is an academic researcher from Stanford University. The author has contributed to research in topics: Microglia & Fluid-attenuated inversion recovery. The author has an hindex of 5, co-authored 8 publications receiving 216 citations. Previous affiliations of Joy Q He include Saint Louis University.
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Journal ArticleDOI
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas,Amira Latif-Hernandez,Melanie R. McReynolds,Aarooran Sivakumaran Durairaj,Qian Wang,Amanda J. Rubin,Amit Joshi,Joy Q He,Esha Gauba,Ling Liu,Congcong Wang,Miles H. Linde,Yuki Sugiura,Peter K. Moon,Ravi Majeti,Makoto Suematsu,Daria Mochly-Rosen,Irving L. Weissman,Frank M. Longo,Joshua D. Rabinowitz,Katrin I. Andreasson +20 more
TL;DR: This article showed that myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation.
Journal ArticleDOI
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.
Gregor Hutter,Johanna Theruvath,Claus Moritz Graef,Michael Zhang,Matthew K. Schoen,Eva Maria Manz,Mariko L. Bennett,Andrew Olson,Tej D. Azad,Rahul Sinha,Carmel T. Chan,Suzana Assad Kahn,Sharareh Gholamin,Christy Wilson,Gerald A. Grant,Joy Q He,Irving L. Weissman,Siddhartha Mitra,Samuel H. Cheshier +18 more
TL;DR: It is shown that tumor-associated microglia are capable of in vivo tumor cell phagocytosis in response to anti-CD47 blockade and the transcriptional profile ofmicroglia shows less of an inflammatory response which makes them a promising target for clinical applications.
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Mu and kappa opioids modulate mouse embryonic stem cell‐derived neural progenitor differentiation via MAP kinases
Jason W. Hahn,Shana Jagwani,Eunhae Kim,Victoria R. Rendell,Joy Q He,Lubov A. Ezerskiy,Robin Wesselschmidt,Carmine J. Coscia,Mariana M. Belcheva +8 more
TL;DR: In this paper, the presence of functional mu opioid receptors and kappa opioid receptors (KOR) in mouse embryonic stem cells and neural progenitors was detected in three stages of their maturation in vitro.
Journal ArticleDOI
Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke.
TL;DR: The scientific rationale for transplanting cells from each of the three broad cell lineages of hematopoietic, mesenchymal, and neural is discussed and an overview of published and ongoing trials using this framework is provided.
Journal ArticleDOI
Neural tube defects in Uganda: follow-up outcomes from a national referral hospital.
Linda W. Xu,Silvia D Vaca,Joy Q He,Juliet Nalwanga,Christine Muhumuza,Joel Kiryabwire,Hussein Ssenyonjo,John Mukasa,Michael Muhumuza,Gerald A. Grant +9 more
TL;DR: There is a great need for improved access to and coordination of care in antenatal, perioperative, and long-term settings to improve morbidity and mortality of spina bifida patients treated at Mulago National Referral Hospital.