P
Paras S. Minhas
Researcher at Stanford University
Publications - 30
Citations - 1509
Paras S. Minhas is an academic researcher from Stanford University. The author has contributed to research in topics: Cognitive decline & Neuroinflammation. The author has an hindex of 12, co-authored 29 publications receiving 775 citations. Previous affiliations of Paras S. Minhas include University of Pittsburgh & Xi'an Jiaotong-Liverpool University.
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Journal ArticleDOI
Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
Amit Joshi,Paras S. Minhas,Shane A. Liddelow,Shane A. Liddelow,Shane A. Liddelow,Bereketeab Haileselassie,Katrin I. Andreasson,Gerald W. Dorn,Daria Mochly-Rosen +8 more
TL;DR: It is shown that the expression of neurotoxic proteins associated with neurodegenerative diseases in microglia alone is sufficient to directly trigger death of naive neurons and to propagate neuronal death through activation of naive astrocytes to the A1 state, without affecting the release of healthy neuroprotective mitochondria.
Journal ArticleDOI
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.
Paras S. Minhas,Ling Liu,Peter K. Moon,Amit Joshi,Christopher Dove,Siddhita D. Mhatre,Kévin Contrepois,Qian Wang,Brittany A. Lee,Michael Coronado,Daniel Bernstein,Michael Snyder,Marie E. Migaud,Ravindra Majeti,Daria Mochly-Rosen,Joshua D. Rabinowitz,Katrin I. Andreasson +16 more
TL;DR: It is demonstrated that cell-autonomous generation of nicotinamide adenine dinucleotide via the kynurenine pathway (KP) regulates macrophage immune function in aging and inflammation and increasing de novo NAD+ generation in immune-challenged or aged macrophages restored oxidative phosphorylation and homeostatic immune responses.
Journal ArticleDOI
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas,Amira Latif-Hernandez,Melanie R. McReynolds,Aarooran Sivakumaran Durairaj,Qian Wang,Amanda J. Rubin,Amit Joshi,Joy Q He,Esha Gauba,Ling Liu,Congcong Wang,Miles H. Linde,Yuki Sugiura,Peter K. Moon,Ravi Majeti,Makoto Suematsu,Daria Mochly-Rosen,Irving L. Weissman,Frank M. Longo,Joshua D. Rabinowitz,Katrin I. Andreasson +20 more
TL;DR: This article showed that myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation.
Journal ArticleDOI
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening
Grant L. Lin,Kelli M. Wilson,Michele Ceribelli,Benjamin Z. Stanton,Pamelyn Woo,Sara Kreimer,Elizabeth Y. Qin,Xiaohu Zhang,James Lennon,Surya Nagaraja,Patrick J. Morris,Michael Quezada,Shawn M. Gillespie,Damien Y. Duveau,Aleksandra M. Michalowski,Paul Shinn,Rajarshi Guha,Marc Ferrer,Carleen Klumpp-Thomas,Sam Michael,Crystal McKnight,Paras S. Minhas,Zina Itkin,Eric H. Raabe,Lu Chen,Reem A. Ghanem,Anna Geraghty,Lijun Ni,Katrin I. Andreasson,Nicholas A Vitanza,Katherine E. Warren,Craig J. Thomas,Michelle Monje +32 more
TL;DR: This study provides a comprehensive single-agent and combinatorial drug screen for DMG and identifies concomitant HDAC and proteasome inhibition as a promising therapeutic strategy that underscores underrecognized metabolic vulnerabilities in DMG.
Journal ArticleDOI
Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity
Qingkun Liu,Emily M. Johnson,Rachel K. Lam,Qian Wang,Hong Bo Ye,Edward N. Wilson,Paras S. Minhas,Ling Liu,Michelle S. Swarovski,Stephanie Tran,Jing Wang,Swapnil Mehta,Xi Yang,Joshua D. Rabinowitz,Samuel Yang,Mehrdad Shamloo,Christoph Mueller,Michelle L. James,Katrin I. Andreasson +18 more
TL;DR: TREM1 is upregulated after stroke and amplifies proinflammatory responses by peripheral CD11b+ myeloid cells in both the ischemic brain and distally in the intestine, and targeting this specific innate immune pathway reduces cerebral injury.