K
Katharina Zimmermann
Researcher at University of Erlangen-Nuremberg
Publications - 53
Citations - 4421
Katharina Zimmermann is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Transient receptor potential channel & Calcitonin gene-related peptide. The author has an hindex of 28, co-authored 52 publications receiving 3856 citations. Previous affiliations of Katharina Zimmermann include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Nociceptors are interleukin-1beta sensors
Alexander M. Binshtok,Haibin Wang,Katharina Zimmermann,Fumimasa Amaya,Daniel Vardeh,Lin Shi,Gary J. Brenner,Ru-Rong Ji,Bruce P. Bean,Clifford J. Woolf,Tarek A. Samad +10 more
TL;DR: It is shown that the proinflammatory cytokine interleukin-1 β (IL-1β), in addition to producing inflammation and inducing synthesis of several nociceptor sensitizers, also rapidly and directly activates nocICEptors to generate action potentials and induce pain hypersensitivity.
Journal ArticleDOI
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures.
Katharina Zimmermann,Andreas Leffler,Alexandru Babes,Cruz Miguel Cendán,Richard W. Carr,Jin-ichi Kobayashi,Carla Nau,John N. Wood,Peter W. Reeh +8 more
TL;DR: This work shows that cooling excitable membranes progressively enhances the voltage-dependent slow inactivation of tetrodotoxin-sensitive VGSCs, and presents strong evidence for a specialized role of Nav1.8 in nociceptors as the critical molecule for the perception of cold pain and pain in the cold.
Journal ArticleDOI
TREK-1, a K+ channel involved in polymodal pain perception
Abdelkrim Alloui,Katharina Zimmermann,Julien Mamet,Fabrice Duprat,Jacques Noël,Jean Chemin,Nicolas Guy,Nicolas Blondeau,Nicolas Voilley,Catherine Rubat-Coudert,Marc Borsotto,Georges Romey,Catherine Heurteaux,Peter W. Reeh,Alain Eschalier,Michel Lazdunski +15 more
TL;DR: It is demonstrated that TREK‐1 qualifies as one of the molecular sensors involved in pain perception and as an attractive target for the development of new analgesics.
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The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception
Jacques Noël,Katharina Zimmermann,Jérôme Busserolles,Jérôme Busserolles,Emanuel Deval,Abdelkrim Alloui,Abdelkrim Alloui,Sylvie Diochot,Nicolas Guy,Marc Borsotto,Peter W. Reeh,Alain Eschalier,Alain Eschalier,Michel Lazdunski +13 more
TL;DR: The mechano‐gated and highly temperature‐sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated, important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs.
Journal ArticleDOI
A TRP channel trio mediates acute noxious heat sensing
Ine Vandewauw,Katrien De Clercq,Marie Mulier,Katharina Held,Silvia Pinto,Nele Van Ranst,Andrei Segal,Thierry Voet,Rudi Vennekens,Katharina Zimmermann,Joris Vriens,Thomas Voets +11 more
TL;DR: Findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP channels, representing a fault-tolerant mechanism to avoid burn injury.