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Abeer M Shaaban
Researcher at Queen Elizabeth Hospital Birmingham
Publications - 191
Citations - 3971
Abeer M Shaaban is an academic researcher from Queen Elizabeth Hospital Birmingham. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 31, co-authored 152 publications receiving 3106 citations. Previous affiliations of Abeer M Shaaban include Leeds General Infirmary & University Hospitals Birmingham NHS Foundation Trust.
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Journal ArticleDOI
Nuclear and Cytoplasmic Expression of ERβ1, ERβ2, and ERβ5 Identifies Distinct Prognostic Outcome for Breast Cancer Patients
Abeer M Shaaban,Andrew R. Green,Suchita Karthik,Yalda Alizadeh,Thomas A. Hughes,Lynn Harkins,Ian O. Ellis,John F.R. Robertson,E.C. Paish,Philippa T. K. Saunders,Nigel P. Groome,Valerie Speirs +11 more
TL;DR: ERβ2 is a powerful prognostic indicator in breast cancer, but nuclear and cytoplasmic expression differentially affect outcome, so measuring these in clinical breast cancer could provide a more comprehensive picture of patient outcome, complementing ERα.
Journal ArticleDOI
Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia.
Abeer M Shaaban,P A O'Neill,Michael P.A. Davies,Ross Sibson,Christopher R. West,Paul H. Smith,Christopher S. Foster +6 more
TL;DR: The original hypothesis that the tissue concentration, relative occurrence, and/or interaction of these two types of estrogen receptor may play an important role in modulating mammary tumorigenesis is supported.
Journal ArticleDOI
Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial.
Nicholas C. Turner,Nicholas C. Turner,B Kingston,Lucy Kilburn,Sarah Kernaghan,Andrew M Wardley,Andrew M Wardley,Iain R. Macpherson,Richard D. Baird,Rebecca Roylance,Rebecca Roylance,Peter Stephens,Olga Oikonomidou,Jeremy P Braybrooke,Mark Tuthill,Jacinta Abraham,Matthew C Winter,Hannah Bye,Mike Hubank,Mike Hubank,Heidrun Gevensleben,Ros Cutts,Claire Snowdon,Daniel Rea,David Cameron,Abeer M Shaaban,Katrina Randle,Sue Martin,Katie Wilkinson,Laura Moretti,Judith M Bliss,A Ring +31 more
TL;DR: The results demonstrate clinically relevant activity of targeted therapies against rare HER2 and AKT1 mutations, and agreement between ctDNA digital PCR and targeted sequencing was 96–99% (n=800, kappa 0·89–0·93).
Journal ArticleDOI
Histopathologic types of benign breast lesions and the risk of breast cancer: case-control study.
Abeer M Shaaban,John P. Sloane,Christopher R. West,F.R. Moore,Christine Jarvis,E M I Williams,Christopher S. Foster +6 more
TL;DR: Improved knowledge of breast carcinogenesis will provide insight for defining high-risk groups thus resulting in improved screening and management regimens, and define, for the first time, the level of risk associated with each of its six subtypes.
Journal ArticleDOI
The rising incidence of male breast cancer.
Valerie Speirs,Abeer M Shaaban +1 more
TL;DR: Male breast cancer incidence is increasing in the UK, paralleling US data which shows a concordant increase over a similar time period and its rising trend, which seems likely to continue, suggests coordinated multi-centre approaches are necessary to accumulate data.