A
Abigail Knecht
Researcher at Broad Institute
Publications - 4
Citations - 223
Abigail Knecht is an academic researcher from Broad Institute. The author has contributed to research in topics: Haematopoiesis & Function (biology). The author has an hindex of 3, co-authored 3 publications receiving 139 citations. Previous affiliations of Abigail Knecht include Harvard University.
Papers
More filters
Journal ArticleDOI
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.
Mati Mann,Arnav Mehta,Arnav Mehta,Carl G. de Boer,Monika S. Kowalczyk,Kevin Y. Lee,Pearce Haldeman,Noga Rogel,Abigail Knecht,Daneyal Farouq,Aviv Regev,Aviv Regev,David Baltimore +12 more
TL;DR: An LT-HSC subset is identified and isolated that regulates myeloid versus lymphoid balance under inflammatory challenge and with age, and it is predicted that several transcription factors regulate the mLT-H SCs gene program and that Klf5, Ikzf1, and Stat3 play an important role in age-related inflammatory myeloids bias.
Journal ArticleDOI
Nuclei multiplexing with barcoded antibodies for single-nucleus genomics
Jellert Gaublomme,Jellert Gaublomme,Bo Li,Bo Li,Cristin McCabe,Abigail Knecht,Yiming Yang,Eugene Drokhlyansky,Nicholas Van Wittenberghe,Julia Waldman,Danielle Dionne,Lan Nguyen,Philip L. De Jager,Bertrand Z. Yeung,Xinfang Zhao,Naomi Habib,Naomi Habib,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev +19 more
TL;DR: An approach for multiplexing snRNA-seq is presented, using sample-barcoded antibodies to uniquely label nuclei from distinct samples, and a computational tool to assign the sample of origin is developed.
Posted ContentDOI
Nuclei multiplexing with barcoded antibodies for single-nucleus genomics
Jellert Gaublomme,Bo Li,Cristin McCabe,Abigail Knecht,Eugene Drokhlyansky,Nicholas Van Wittenberghe,Julia Waldman,Danielle Dionne,Lan Nguyen,Philip L. De Jager,Bertrand Z. Yeung,Xinfang Zhao,Naomi Habib,Orit Rozenblatt-Rosen,Aviv Regev +14 more
TL;DR: This work presents an approach for multiplexing snRNA-seq, using sample-barcoded antibodies against the nuclear pore complex to uniquely label nuclei from distinct samples, and demonstrates that nucleus hashing does not significantly alter the recovered transcriptome profiles.
Posted ContentDOI
Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities
TL;DR: This paper showed that immunity proteins from a newly defined protein family can bind and protect against non-cognate PD-(D/E)XK-containing effectors from diverse phyla.