P
Pearce Haldeman
Researcher at California Institute of Technology
Publications - 3
Citations - 125
Pearce Haldeman is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Protein subunit & Haematopoiesis. The author has an hindex of 3, co-authored 3 publications receiving 80 citations. Previous affiliations of Pearce Haldeman include University of Arizona.
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Journal ArticleDOI
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.
Mati Mann,Arnav Mehta,Arnav Mehta,Carl G. de Boer,Monika S. Kowalczyk,Kevin Y. Lee,Pearce Haldeman,Noga Rogel,Abigail Knecht,Daneyal Farouq,Aviv Regev,Aviv Regev,David Baltimore +12 more
TL;DR: An LT-HSC subset is identified and isolated that regulates myeloid versus lymphoid balance under inflammatory challenge and with age, and it is predicted that several transcription factors regulate the mLT-H SCs gene program and that Klf5, Ikzf1, and Stat3 play an important role in age-related inflammatory myeloids bias.
Journal ArticleDOI
Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors
A. F. M. Tariqul Islam,Margarethakay Scavello,Pouya Lotfi,Dustin Daniel,Pearce Haldeman,Pearce Haldeman,Pascale G. Charest +6 more
TL;DR: The findings reveal that caffeine considerably affects the cAMP-induced chemotactic signaling pathways in Dictyostelium, most likely acting through multiple targets that include PI3K and mTORC2.
Journal ArticleDOI
The cAMP-induced G protein subunits dissociation monitored in live Dictyostelium cells by BRET reveals two activation rates, a positive effect of caffeine and potential role of microtubules.
A. F. M. Tariqul Islam,Haicen Yue,Margarethakay Scavello,Pearce Haldeman,Wouter-Jan Rappel,Pascale G. Charest +5 more
TL;DR: It is found that cAMP induces the cAR1-mediated dissociation of the G protein subunits to a similar extent in both undifferentiated and differentiated cells, suggesting that only a small number of c AR1 (as expressed in undifferentiation cells) is necessary to induce the full activation of Gα2βγ.