Adam Mechler

TL;DR: The OptiPrepTM density gradient method was superior in isolating pure exosomal populations, devoid of highly abundant plasma proteins, and in the context of cellular uptake, the isolated exosomes were able to fuse with target cells revealing that they were indeed biologically active.

TL;DR: It is ascertained that cancer cells facilitate oncogenesis by the secretion of mutant and oncoproteins into the tumor microenvironment via exosomes and ectosomes.

TL;DR: Computational analysis of the atomic force microscopy phase mode imaging reveals a significantly higher interfacial energy for open hemichannels that results from the interactions between theatomic force microscope probe and the hydrophobic domains, indicating that hydrophilic extracellular domains of connexins regulate calcium-dependent conformational changes.

TL;DR: It is found that caerin inserted into the bilayer in a transmembrane manner, regardless of concentration and phospholipid composition consistent with a pore-forming mechanism, which is consistent with the "carpet" mechanism of Australian tree frogs.