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Adam Richman
Publications - 6
Citations - 862
Adam Richman is an academic researcher. The author has contributed to research in topics: Plasmodium falciparum & Anopheles. The author has an hindex of 4, co-authored 6 publications receiving 770 citations.
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Journal ArticleDOI
Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity
J. E. Epstein,Krishnansu S. Tewari,Kirsten E. Lyke,B. K. L. Sim,Peter F. Billingsley,Matthew B. Laurens,Matthew B. Laurens,Anusha Gunasekera,Sumana Chakravarty,Eric R. James,Martha Sedegah,Adam Richman,Soundarapandian Velmurugan,Sharina Reyes,Ming Lin Li,Kathryn Tucker,Adriana Ahumada,Adam Ruben,Tao Li,Richard E. Stafford,Abraham G. Eappen,Cindy Tamminga,Jason W. Bennett,Christian F. Ockenhouse,Jittawadee Murphy,Jack Komisar,N. Thomas,Mark Loyevsky,Ashley J. Birkett,Christopher V. Plowe,Christopher V. Plowe,Christian Loucq,Robert R. Edelman,Thomas L. Richie,Robert A. Seder,Stephen L. Hoffman +35 more
TL;DR: The results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Plasmodium falciparum malaria and suboptimally immunogenic and protective.
Journal ArticleDOI
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.
Stephen L. Hoffman,Peter F. Billingsley,Eric R. James,Adam Richman,Mark Loyevsky,Tao Li,Sumana Chakravarty,Anusha Gunasekera,Rana Chattopadhyay,Minglin Li,Richard E. Stafford,Adriana Ahumada,Judith E. Epstein,Martha Sedegah,Sharina Reyes,Thomas L. Richie,Kirsten E. Lyke,Robert R. Edelman,Matthew B. Laurens,Christopher V. Plowe,B. Kim Lee Sim +20 more
TL;DR: Efforts are now focused on how best to achieve submission of a successful Biologics License Application and introduce the vaccine to the primary target population of African children in the shortest possible period of time.
Journal ArticleDOI
Plasmodium falciparum malaria challenge by the bite of aseptic Anopheles stephensi mosquitoes: results of a randomized infectivity trial.
Kirsten E. Lyke,Matthew B. Laurens,Matthew Adams,Peter F. Billingsley,Adam Richman,Mark Loyevsky,Sumana Chakravarty,Christopher V. Plowe,B. Kim Lee Sim,Robert R. Edelman,Stephen L. Hoffman +10 more
TL;DR: The use of aseptic, cGMP-compliant P. falciparum-infected mosquitoes is safe, is associated with a precise prepatent period compared to the standard model and appears more efficient than the standard approach.
Journal ArticleDOI
Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum.
Tao Li,Abraham G. Eappen,Adam Richman,Peter F. Billingsley,Yonas Abebe,Minglin Li,Debbie Padilla,Isabel Rodriguez-Barraquer,B. Kim Lee Sim,Stephen L. Hoffman +9 more
TL;DR: A robust capacity to perform the standard Plasmodium falciparum membrane-feeding assay in a medium-to-high throughput format, suitable for assessing large numbers of experimental samples of candidate antibodies or drugs is demonstrated.
Induction of malaria in volunteers by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
M. Bijker,Meta Roestenberg,B. Kim,Lee Sim,Peter F. Billingsley,Eric R. James,Anne C. Teirlinck,Dunja Zimmerman,Karina Teelen,Theo Arens,Pieter Beckers,Annemieke Jansens,Krystelle Nganou-Makamdop,Anja Scholzen,Jorien Wiersma,Anusha Gunasekera,Adam Richman,Sumana Chakravarty,Anita Manoj,Abraham G. Eappen +19 more
TL;DR: The capacity to infect volunteers by intradermal (ID) injection of aseptic, purified, vialed, cryopreserved PfSPZ (PfSPZ Challenge) produced by Sanaria Inc is assessed.