M
Martha Sedegah
Researcher at Naval Medical Research Center
Publications - 125
Citations - 9841
Martha Sedegah is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Plasmodium yoelii & Circumsporozoite protein. The author has an hindex of 45, co-authored 120 publications receiving 9304 citations. Previous affiliations of Martha Sedegah include Pan American Health Organization & Walter Reed Army Institute of Research.
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Journal ArticleDOI
Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
Ruobing Wang,Denise L. Doolan,Thong P. Le,Richard C. Hedstrom,Kevin M. Coonan,Yupin Charoenvit,Trevor R. Jones,Peter Hobart,Michal Margalith,Jennifer Ng,Walter R. Weiss,Martha Sedegah,Charles de Taisne,Jon Norman,Stephen L. Hoffman +14 more
TL;DR: This first demonstration in healthy naïve humans of the induction of CD8+ C TLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.
Journal ArticleDOI
Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites
Stephen L. Hoffman,Lucy M. L. Goh,Thomas C. Luke,Imogene Schneider,Thong P. Le,Denise L. Doolan,Denise L. Doolan,John B. Sacci,John B. Sacci,Patricia de la Vega,Patricia de la Vega,Megan Dowler,Chris Paul,Daniel M. Gordon,José A. Stoute,L. W. Preston Church,Martha Sedegah,Martha Sedegah,D. Gray Heppner,W. Ripley Ballou,Thomas L. Richie +20 more
TL;DR: These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.
Journal ArticleDOI
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Robert A. Seder,Lee-Jah Chang,Mary E. Enama,Kathryn L Zephir,Uzma N. Sarwar,Ingelise J. Gordon,La Sonji A. Holman,Eric R. James,Peter F. Billingsley,Anusha Gunasekera,Adam D. Richman,Sumana Chakravarty,Anita Manoj,Soundarapandian Velmurugan,Ming Lin Li,Adam Ruben,Tao Li,Abraham G. Eappen,Richard E. Stafford,Sarah H. Plummer,Cynthia S. Hendel,Laura Novik,Pamela Costner,Floreliz Mendoza,Jamie G. Saunders,Martha Nason,Jason H. Richardson,Jittawadee Murphy,Silas A. Davidson,Thomas L. Richie,Martha Sedegah,Awalludin Sutamihardja,Gary A. Fahle,Kirsten E. Lyke,Matthew B. Laurens,Matthew B. Laurens,Mario Roederer,Kavita Tewari,Judith E. Epstein,B. Kim Lee Sim,Julie E. Ledgerwood,Barney S. Graham,Stephen L. Hoffman +42 more
TL;DR: There is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.
Journal ArticleDOI
Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity
J. E. Epstein,Krishnansu S. Tewari,Kirsten E. Lyke,B. K. L. Sim,Peter F. Billingsley,Matthew B. Laurens,Matthew B. Laurens,Anusha Gunasekera,Sumana Chakravarty,Eric R. James,Martha Sedegah,Adam Richman,Soundarapandian Velmurugan,Sharina Reyes,Ming Lin Li,Kathryn Tucker,Adriana Ahumada,Adam Ruben,Tao Li,Richard E. Stafford,Abraham G. Eappen,Cindy Tamminga,Jason W. Bennett,Christian F. Ockenhouse,Jittawadee Murphy,Jack Komisar,N. Thomas,Mark Loyevsky,Ashley J. Birkett,Christopher V. Plowe,Christopher V. Plowe,Christian Loucq,Robert R. Edelman,Thomas L. Richie,Robert A. Seder,Stephen L. Hoffman +35 more
TL;DR: The results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Plasmodium falciparum malaria and suboptimally immunogenic and protective.
Journal ArticleDOI
Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.
TL;DR: The utility of plasmid DNA immunization against a nonviral infection is demonstrated and this method of immunization provides an important alternative for rapid identification of protective B- and T-cell epitopes and for construction of vaccines to prevent malaria and other infectious diseases.