A
Anita Manoj
Publications - 22
Citations - 2447
Anita Manoj is an academic researcher. The author has contributed to research in topics: PfSPZ vaccine & Vaccination. The author has an hindex of 12, co-authored 21 publications receiving 1859 citations.
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Journal ArticleDOI
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Robert A. Seder,Lee-Jah Chang,Mary E. Enama,Kathryn L Zephir,Uzma N. Sarwar,Ingelise J. Gordon,La Sonji A. Holman,Eric R. James,Peter F. Billingsley,Anusha Gunasekera,Adam D. Richman,Sumana Chakravarty,Anita Manoj,Soundarapandian Velmurugan,Ming Lin Li,Adam Ruben,Tao Li,Abraham G. Eappen,Richard E. Stafford,Sarah H. Plummer,Cynthia S. Hendel,Laura Novik,Pamela Costner,Floreliz Mendoza,Jamie G. Saunders,Martha Nason,Jason H. Richardson,Jittawadee Murphy,Silas A. Davidson,Thomas L. Richie,Martha Sedegah,Awalludin Sutamihardja,Gary A. Fahle,Kirsten E. Lyke,Matthew B. Laurens,Matthew B. Laurens,Mario Roederer,Kavita Tewari,Judith E. Epstein,B. Kim Lee Sim,Julie E. Ledgerwood,Barney S. Graham,Stephen L. Hoffman +42 more
TL;DR: There is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.
Journal ArticleDOI
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine
Benjamin Mordmüller,Güzin Surat,Heimo Lagler,Heimo Lagler,Sumana Chakravarty,Andrew S. Ishizuka,Albert Lalremruata,Markus Gmeiner,Joseph J. Campo,Meral Esen,Adam Ruben,Jana Held,Carlos Lamsfus Calle,Juliana Boex Mengue,Tamirat Gebru,Javier Ibáñez,Mihály Sulyok,Eric R. James,Peter F. Billingsley,Natasha Kc,Anita Manoj,Tooba Murshedkar,Anusha Gunasekera,Abraham G. Eappen,Tao Li,Richard E. Stafford,Minglin Li,Phil Felgner,Robert A. Seder,Thomas L. Richie,B. Kim Lee Sim,Stephen L. Hoffman,Peter G. Kremsner +32 more
TL;DR: PfSPZ-CVac is a highly efficacious vaccine candidate that could be used for combination mass drug administration and a mass vaccination program approach to eliminate malaria from geographically defined areas when able to optimize the immunization regimen.
Journal ArticleDOI
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.
Andrew S. Ishizuka,Kirsten E. Lyke,Adam DeZure,Andrea A. Berry,Thomas L. Richie,Floreliz Mendoza,Mary E. Enama,Ingelise J. Gordon,Lee-Jah Chang,Lee-Jah Chang,Uzma N. Sarwar,Uzma N. Sarwar,Kathryn L Zephir,LaSonji A. Holman,Eric R. James,Peter F. Billingsley,Anusha Gunasekera,Sumana Chakravarty,Anita Manoj,Minglin Li,Adam Ruben,Tao Li,Abraham G. Eappen,Richard E. Stafford,Natasha K C,Tooba Murshedkar,Hope Decederfelt,Sarah H. Plummer,Cynthia S. Hendel,Laura Novik,Pamela Costner,Jamie G. Saunders,Matthew B. Laurens,Christopher V. Plowe,Barbara J. Flynn,William R Whalen,John Paul Todd,Jay Noor,Srinivas S. Rao,Srinivas S. Rao,Kailan Sierra-Davidson,Geoffrey M. Lynn,Judith E. Epstein,Margaret A. Kemp,Gary A. Fahle,Sebastian A. Mikolajczak,Matthew Fishbaugher,Brandon K. Sack,Stefan H. I. Kappe,Silas A. Davidson,Lindsey S. Garver,Niklas K. Björkström,Martha Nason,Barney S. Graham,Mario Roederer,B. Kim Lee Sim,Stephen L. Hoffman,Julie E. Ledgerwood,Robert A. Seder +58 more
TL;DR: It is suggested that PfSPZ Vaccine conferred durable protection to malaria through long-lived tissue-resident T cells and that administration of higher doses may further enhance protection.
Journal ArticleDOI
Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial
Mahamadou S. Sissoko,Sara A. Healy,Abdoulaye Katile,Freda Omaswa,Irfan Zaidi,Erin E. Gabriel,Bourama Kamate,Yacouba Samake,Merepen A. Guindo,Amagana Dolo,Amadou Niangaly,Karamoko Niaré,Amatigue Zeguime,Kourane Sissoko,Hama Diallo,Ismaila Thera,Kelly Ding,Michael P. Fay,Elise M. O’Connell,Thomas B. Nutman,Sharon Wong-Madden,Tooba Murshedkar,Adam Ruben,Minglin Li,Yonas Abebe,Anita Manoj,Anusha Gunasekera,Sumana Chakravarty,B. Kim Lee Sim,Peter F. Billingsley,Eric R. James,Michael Walther,Thomas L. Richie,Stephen L. Hoffman,Ogobara K. Doumbo,Patrick E. Duffy +35 more
TL;DR: PfSPZ Vaccine showed significant protection in African adults against P falciparum infection throughout an entire malaria season and was well tolerated and safe.
Journal ArticleDOI
Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection
Kirsten E. Lyke,Andrew S. Ishizuka,Andrea A. Berry,Sumana Chakravarty,Adam DeZure,Mary E. Enama,Eric R. James,Peter F. Billingsley,Anusha Gunasekera,Anita Manoj,Minglin Li,Adam Ruben,Tao Li,Abraham G. Eappen,Richard E. Stafford,Natasha Kc,Tooba Murshedkar,Floreliz Mendoza,Ingelise J. Gordon,Kathryn L Zephir,LaSonji A. Holman,Sarah H. Plummer,Cynthia S. Hendel,Laura Novik,Pamela Costner,Jamie G. Saunders,Nina M. Berkowitz,Barbara J. Flynn,Martha Nason,Lindsay S. Garver,Matthew B. Laurens,Christopher V. Plowe,Thomas L. Richie,Barney S. Graham,Mario Roederer,B. Kim Lee Sim,Julie E. Ledgerwood,Stephen L. Hoffman,Robert A. Seder +38 more
TL;DR: Evidence is provided that this Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine) induces antigen-specific IFN-γ-producing CD8 and CD4 T cells that recognize both the homologous and the heterologous Pf strain.