J
J. E. Epstein
Researcher at Naval Medical Research Center
Publications - 6
Citations - 838
J. E. Epstein is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Plasmodium falciparum & Antigen. The author has an hindex of 6, co-authored 6 publications receiving 783 citations.
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Journal ArticleDOI
Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity
J. E. Epstein,Krishnansu S. Tewari,Kirsten E. Lyke,B. K. L. Sim,Peter F. Billingsley,Matthew B. Laurens,Matthew B. Laurens,Anusha Gunasekera,Sumana Chakravarty,Eric R. James,Martha Sedegah,Adam Richman,Soundarapandian Velmurugan,Sharina Reyes,Ming Lin Li,Kathryn Tucker,Adriana Ahumada,Adam Ruben,Tao Li,Richard E. Stafford,Abraham G. Eappen,Cindy Tamminga,Jason W. Bennett,Christian F. Ockenhouse,Jittawadee Murphy,Jack Komisar,N. Thomas,Mark Loyevsky,Ashley J. Birkett,Christopher V. Plowe,Christopher V. Plowe,Christian Loucq,Robert R. Edelman,Thomas L. Richie,Robert A. Seder,Stephen L. Hoffman +35 more
TL;DR: The results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Plasmodium falciparum malaria and suboptimally immunogenic and protective.
Journal ArticleDOI
A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.
Susanna Dunachie,Michael Walther,J. E. Epstein,Sheila M. Keating,Tamara Berthoud,Laura Andrews,Rikke Fredslund Andersen,Philip Bejon,N Goonetilleke,Ian D. Poulton,Daniel P. Webster,G.A. Butcher,Kate E. Watkins,Robert E. Sinden,G. L. Levine,Thomas L. Richie,Joerg Schneider,David C. Kaslow,Sarah C. Gilbert,Daniel J. Carucci,A Hill +20 more
TL;DR: The vaccines were well tolerated and immunogenic, with the DDM-ME TRAP regimen producing stronger ex vivo IFN-γ ELISPOT responses thanDDM-CS, and partial protection against P. falciparum sporozoite challenge in the present study.
Journal ArticleDOI
Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis.
Kazue Takahashi,Judith Gordon,Hong Liu,Kedarnath N. Sastry,J. E. Epstein,Monica Motwani,Inga Laursen,Steffen Thiel,Jens C. Jensenius,Michael C. Carroll,R. Alan B. Ezekowitz +10 more
TL;DR: The results indicate that MBL-A is a modulator of inflammation in vivo and in vitro in the mouse and that the role of MBL may extend beyond its role as an opsonin.
Journal ArticleDOI
Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF.
Martha Sedegah,Yupin Charoenvit,Joao C. Aguiar,John B. Sacci,John B. Sacci,Richard C. Hedstrom,Sanjai Kumar,Sanjai Kumar,Arnel Belmonte,David E. Lanar,Trevor R. Jones,Esteban Abot,Pierre Druilhe,Giampietro Corradin,J. E. Epstein,Thomas L. Richie,Daniel J. Carucci,Stephen L. Hoffman +17 more
TL;DR: In this article, the immunogenicity of GMP-produced plasmids encoding five Plasmodium falciparum proteins, PfCSP, PfSSP2, PfEXP1, PfLSA1, and PfSSA3, given as a mixture, or alone, was assessed.
Journal ArticleDOI
Early Gamma Interferon and Interleukin-2 Responses to Vaccination Predict the Late Resting Memory in Malaria-Naive and Malaria-Exposed Individuals
Philip Bejon,Philip Bejon,Sheila M. Keating,Jedidah Mwacharo,Oscar Kai,Susanna Dunachie,Michael Walther,Tamara Berthoud,Trudie Lang,J. E. Epstein,Daniel J. Carucci,Philippe Moris,Joe Cohen,Sarah C. Gilbert,Norbert Peshu,Kevin Marsh,Kevin Marsh,Adrian V. S. Hill,Adrian V. S. Hill +18 more
TL;DR: It is demonstrated that double-cytokine-producing cells were highly predictive of memory in malaria-exposed volunteers and may be useful in predicting vaccinations most likely to generate stable, long-term memory responses.