A
Adarsha P. Malla
Researcher at Johns Hopkins University
Publications - 23
Citations - 264
Adarsha P. Malla is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nucleus accumbens & Dopamine. The author has an hindex of 5, co-authored 21 publications receiving 128 citations. Previous affiliations of Adarsha P. Malla include University of Maryland, Baltimore & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.
Chirag Vasavda,Ruchita Kothari,Adarsha P. Malla,Robert Tokhunts,Anthony Lin,Ming Ji,Cristina Ricco,Risheng Xu,Harry Saavedra,Juan I. Sbodio,Adele M. Snowman,Lauren K. Albacarys,Lynda D. Hester,Thomas W. Sedlak,Bindu D. Paul,Solomon H. Snyder +15 more
TL;DR: It is found that bilirubin's redox activity is particularly important in the brain, where it prevents excitotoxicity and neuronal death by scavenging O2⋅- during NMDA neurotransmission.
Journal ArticleDOI
Transcranial recording of electrophysiological neural activity in the rodent brain in vivo using functional photoacoustic imaging of near-infrared voltage-sensitive dye
Jeeun Kang,Haichong K. Zhang,Shilpa D. Kadam,Fedorko Julie,Heather Valentine,Adarsha P. Malla,Ping Yan,Maged M. Harraz,Jin U. Kang,Arman Rahmim,Albert Gjedde,Albert Gjedde,Leslie M. Loew,Dean F. Wong,Emad M. Boctor +14 more
TL;DR: The findings demonstrate that the near-infrared fPA VSD imaging is a promising tool for in vivo recording of brain activities through intact scalp, which would pave a way to its future translation in real time human brain imaging.
Journal ArticleDOI
Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis.
Urbain Weyemi,Bindu D. Paul,Deeya Bhattacharya,Adarsha P. Malla,Myriem Boufraqech,Maged M. Harraz,William M. Bonner,Solomon H. Snyder +7 more
TL;DR: A role for H2AX in mitochondrial homeostasis associated with neuroprotection is established and it is established that this neural failure stems from impairment of mitochondrial function and repression of the mitochondrial biogenesis gene PGC-1α.
Journal ArticleDOI
D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain.
Evan R. Semenza,Maged M. Harraz,Efrat Abramson,Adarsha P. Malla,Chirag Vasavda,Moataz M. Gadalla,Michael D. Kornberg,Solomon H. Snyder,Robin Roychaudhuri +8 more
TL;DR: Using chiral high-performance liquid chromatography and a stereospecific luciferase assay, this paper identified endogenous d-cysteine in the mammalian brain and implicate it as a physiologic regulator of NPC homeostasis in the developing brain.
Journal ArticleDOI
Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.
Jeeun Kang,Shilpa D. Kadam,Joshua S. Elmore,Brennan J. Sullivan,Heather Valentine,Adarsha P. Malla,Maged M. Harraz,Arman Rahmim,Arman Rahmim,Jin U. Kang,Leslie M. Loew,Michael H. Baumann,Anthony A. Grace,Albert Gjedde,Emad M. Boctor,Dean F. Wong +15 more
TL;DR: Transcranial fPA VSD imaging distinguished focal glutamate loads in rat hippocampus, based on the VSD redistribution mechanism sensitive to electrophysiologic membrane potential, and suggests the future utility of this emerging technology in laboratory and clinical sciences as an innovative functional neuroimaging modality.