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Adriana E. Manzi
Researcher at University of California, San Diego
Publications - 26
Citations - 953
Adriana E. Manzi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 13, co-authored 26 publications receiving 936 citations. Previous affiliations of Adriana E. Manzi include University of California, Berkeley.
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Journal ArticleDOI
High-pressure liquid chromatography of sialic acids on a pellicular resin anion-exchange column with pulsed amperometric detection: A comparison with six other systems☆
TL;DR: A new method for the separation of sialic acids at neutral pH on a Carbopac PA-1 anion-exchange column of pellicular resin, with pulsed amperometric detection following postcolumn addition of alkali is reported.
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New sialic acids from biological sources identified by a comprehensive and sensitive approach: liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) of SIA quinoxalinones
TL;DR: This new approach characterizes sialic acids using electrospray ionization-mass spectrometry (ESI-MS) to monitor the HPLC separation of their DMB (1,2-diamino-4,5-methylenedioxy-benzene) derivatives (quinoxalinones) and identified 28 different siali acids, including the following new species.
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Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.
TL;DR: In this article, the melanoma-associated oncofetal glycosphingolipid antigen 9-O-acetyl-GD3, a disialoganglioside Oacetylated at the 9-position of the outer sialic acid residue, was examined.
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Intramolecular self-cleavage of polysialic acid.
TL;DR: The instability of PSA appears to result from intramolecular self-cleavage of the glycosidic bonds of internal Sia units, in which the adjacent carboxyl group with a high pKa acts as a proton donor for general acid catalysis.
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Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures.
Adriana E. Manzi,Karin E. Norgard-Sumnicht,Sulabha P Argade,Jamey D. Marth,Herman van Halbeek,Ajit Varki +5 more
TL;DR: It is found that nano-NMR spectroscopy of whole mixtures of N- and O-glycans can complement HPLC profiling methods for elucidating structural details, and recovery of each major class of glycans is as good or better than with conventional approaches for isolating individual classes.