Adriano Taddeo

TL;DR: In this paper, the authors used isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme (ACE2) and increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model.

TL;DR: Findings identify proteasome inhibitors as a putative therapeutic option for patients with refractory SLE by targeting PCs and type-I IFN activity, but these results must be confirmed in controlled trials.

TL;DR: Observations may provide new insight into the immunomodulatory properties of human defensins and may aid the exploration of new therapeutic strategies to potentiate antimicrobial and antitumor immunity.

TL;DR: In SLE-prone NZB/W F1 mice, autoreactive LLPCs are generated throughout life, and their regeneration after depletion was achieved only by combining a cycle of bortezomib with maintenance therapy, for example cyclophosphamide.

TL;DR: It is suggested that circulating endothelial progenitors from KS patients are KSHV-infected and support viral productive replication and may therefore represent potential virus reservoirs and putative precursors of KS spindle cells.