Lorenz Ulrich

TL;DR: In this paper, the authors used isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme (ACE2) and increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model.

TL;DR: Cattle inoculated with severe acute respiratory syndrome coronavirus 2 and kept them together with 3 uninoculated cattle observed viral replication and specific seroreactivity in 2 inoculated animals, despite high levels of preexisting antibody titers against a bovine betacoronavirus.

TL;DR: A versatile and reliable ELISA protocol was established that enables high‐throughput antibody detection in a broad range of animal species, which may be used for outbreak investigations, to assess the seroprevalence in susceptible species or to screen for reservoir or intermediate hosts.

TL;DR: While the D614G substitution results in subtle increases in binding and replication in vitro, it provides a real competitive advantage in vivo, particularly during the transmission bottle neck, providing an explanation for the global predominance of S-614G variant among the SARS-CoV-2 viruses currently circulating.

TL;DR: In this paper, spike encoding mRNA vaccines (CVnCoV and CV2CoV) against the ancestral strain and the VOC B.1.351 was tested in a K18-hACE2 transgenic mouse model.