Nadine Ebert

TL;DR: In this paper, the authors used isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme (ACE2) and increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model.

TL;DR: A yeast-based synthetic genomics platform is used to reconstruct and characterize large RNA viruses from synthetic DNA fragments; this technique will facilitate the rapid analysis of RNA viruses, such as SARS-CoV-2, during an outbreak.

TL;DR: The virucidal activity of World Health Organization–recommended hand rub formulations, at full strength and multiple dilutions, and of the active ingredients were determined and all disinfectants demonstrated efficient virus inactivation.

TL;DR: The full functionality of a yeast-based synthetic genomics platform for the genetic reconstruction of diverse RNA viruses, including members of the Coronaviridae, Flaviviridae and Paramyxoviridae families are shown.

TL;DR: The results show that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis and advance the understanding of immune-mediated control of CoV in vitro and in vivo—knowledge that could help inform strategies to combat infection by emerging CoVs.