M
Michael W.Y. Chan
Researcher at National Chung Cheng University
Publications - 178
Citations - 8137
Michael W.Y. Chan is an academic researcher from National Chung Cheng University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 43, co-authored 160 publications receiving 7154 citations. Previous affiliations of Michael W.Y. Chan include City University of Hong Kong & University of Hong Kong.
Papers
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Journal ArticleDOI
Identification and characterization of ovarian cancer-initiating cells from primary human tumors.
Shu Zhang,Curt Balch,Michael W.Y. Chan,Hung Cheng Lai,Daniela Matei,Jeanne M. Schilder,Pearlly S. Yan,Tim H M Huang,Kenneth P. Nephew +8 more
TL;DR: It is asserted that epithelial ovarian cancers derive from a subpopulation of CD44(+)CD117(+) cells, thus representing a possible therapeutic target for this devastating disease.
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FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
Tao Zuo,Lizhong Wang,Carl Morrison,Xing Chang,Huiming Zhang,Weiquan Li,Yan Liu,Yin Wang,Xingluo Liu,Michael W.Y. Chan,Jin-Qing Liu,Richard R. Love,Chang Gong Liu,Virginia Godfrey,Rulong Shen,Tim H M Huang,Tianyu Yang,Bae Keun Park,Cun-Yu Wang,Pan Zheng,Yang Liu +20 more
TL;DR: The data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.
Journal Article
Hypermethylation of Multiple Genes in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients
Michael W.Y. Chan,Lun W. Chan,Nelson L.S. Tang,Joanna H.M. Tong,Kwok W. Lo,Tin L. Lee,Ho Y. Cheung,Wai S. Wong,Peter S.F. Chan,Fernand Mac-Moune Lai,Ka F. To +10 more
TL;DR: In this paper, the methylation status of seven genes (RAR β, DAPK, E-cadherin, p16, p15, GSTP1, and MGMT) was analyzed by methylation-specific PCR.
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Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner.
Adam W. Studebaker,Gianluca Storci,Jillian L. Werbeck,Pasquale Sansone,A. Kate Sasser,Simona Tavolari,Tim H M Huang,Michael W.Y. Chan,Frank C. Marini,Thomas J. Rosol,Massimiliano Bonafè,Brett Hall,Brett Hall +12 more
TL;DR: The direct correlation between the ability of breast, lung, and bone fibroblasts to enhance ERalpha-positive breast cancer cell growth and the level of soluble interleukin-6 (IL-6) produced by each organ-specific fibroblast is found, and fibro Blast-mediated growth enhancement was inhibited by the removal or inhibition of IL-6.
Journal ArticleDOI
Identification of novel DNA methylation markers in cervical cancer.
Hung Cheng Lai,Ya-Wen Lin,Tim H M Huang,Pearlly S. Yan,Rui Lan Huang,Hui Chen Wang,Joseph Liu,Michael W.Y. Chan,Tang-Yuan Chu,Chien An Sun,Cheng Chang,Mu Hsien Yu +11 more
TL;DR: 6 genes (SOX1, PAX1, LMX1A, NKX6‐1, WT1 and ONECUT1) more frequently methylated in SCC tissues are reported, suggesting they may be a promising approach for the screening of cervical cancers.