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Agnes A.S. Takeda
Researcher at Sao Paulo State University
Publications - 20
Citations - 414
Agnes A.S. Takeda is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Nuclear localization sequence & Nuclear transport. The author has an hindex of 9, co-authored 20 publications receiving 349 citations. Previous affiliations of Agnes A.S. Takeda include University of São Paulo.
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Journal ArticleDOI
Structural Biology and Regulation of Protein Import into the Nucleus
Mary Christie,Chiung-Wen Chang,Chiung-Wen Chang,Gergely Róna,Kate Smith,Alastair G. Stewart,Agnes A.S. Takeda,Marcos R.M. Fontes,Murray Stewart,Beáta G. Vértessy,Jade K. Forwood,Bostjan Kobe +11 more
TL;DR: The structural basis of the principal nuclear import pathways and the molecular basis of their regulation are reviewed and post-translational modifications, particularly phosphorylation, constitute key regulatory mechanisms operating in these pathways.
Journal ArticleDOI
Structural basis of importin-α-mediated nuclear transport for Ku70 and Ku80.
TL;DR: The prospect of nuclear import of Ku70 and Ku80 independently of each other provides a powerful regulatory mechanism for the function of the Ku70/Ku80 heterodimer and independent functions of the two proteins.
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Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity.
TL;DR: Comparison of BthA-I-BPB with two other BPB-inhibited PLA(2) structures suggests that in the absence of Na(+) ions at the Ca(2+)-binding loop, this loop and other regions of the PLA(1)s undergo structural changes, which may be related to the oligomeric structural changes.
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Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms
João Henrique Maia Assumpção,Agnes A.S. Takeda,José Maurício Sforcin,Cláudia Aparecida Rainho +3 more
TL;DR: Findings suggest that propolis are a promising source for epi-drugs discovery, and some chemical compound present in the EEP has DNMTi activity and can revert the epigenetic silencing of the tumor suppressor RASSF1A.
Journal ArticleDOI
Structure of Importin-α from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
Natalia E. Bernardes,Agnes A.S. Takeda,Thiago R. Dreyer,Fernanda Zanolli Freitas,Maria Célia Bertolini,Marcos R.M. Fontes +5 more
TL;DR: This work determined the first crystal structure of an Impα from a filamentous fungus which is also the highest resolution Impα structure already solved to date and performed calorimetric analysis to determine the affinity and thermodynamic parameters of the interaction between Imp-α and the classical SV40 NLS peptide.