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Agnieszka Swierczak
Researcher at University of Edinburgh
Publications - 7
Citations - 792
Agnieszka Swierczak is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cancer & Tumor microenvironment. The author has an hindex of 6, co-authored 7 publications receiving 499 citations. Previous affiliations of Agnieszka Swierczak include Peter MacCallum Cancer Centre.
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Journal ArticleDOI
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
Luca Cassetta,Stamatina Fragkogianni,Andrew H. Sims,Agnieszka Swierczak,Lesley M. Forrester,Hui Zhang,Daniel Y.H. Soong,Tiziana Cotechini,Pavana Anur,Elaine Y. Lin,Antonella Fidanza,Martha Lopez-Yrigoyen,Michael Millar,Alexandra Urman,Zhichao Ai,Paul T. Spellman,E. Shelley Hwang,J Michael Dixon,Lisa Wiechmann,Lisa M. Coussens,Harriet O. Smith,Jeffrey W. Pollard,Jeffrey W. Pollard +22 more
TL;DR: It is shown that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer and an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8 is identified.
Journal ArticleDOI
The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Agnieszka Swierczak,Andrew D. Cook,Jason C Lenzo,Christina Restall,Judy Doherty,Robin L. Anderson,John A. Hamilton +6 more
TL;DR: The results indicate that the role of the CSF-1R/CSF- 1 system in breast cancer is far more complex than originally proposed, and requires further investigation as a therapeutic target.
Journal ArticleDOI
Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy
Olga A. Martin,Olga A. Martin,Robin L. Anderson,Prudence A Russell,R Ashley Cox,Alesia Ivashkevich,Alesia Ivashkevich,Agnieszka Swierczak,Judy Doherty,Daphne Jacobs,Jai Smith,Shankar Siva,Patricia Daly,David Ball,David Ball,Roger F. Martin,Roger F. Martin,Michael MacManus,Michael MacManus +18 more
TL;DR: The findings provide a rationale for the development of strategies to reduce the concentration of viable CTCs by modulating RT fractionation or by coadministering systemic therapies.
Book ChapterDOI
Isolation of Mouse and Human Tumor-Associated Macrophages
Luca Cassetta,Roy Noy,Agnieszka Swierczak,Gaël Sugano,Harriet O. Smith,Lisa Wiechmann,Jeffrey W. Pollard +6 more
TL;DR: An optimized protocol for the efficient isolation and extraction of resident macrophages and TAMs from human and mouse tissues by using multicolor flow cytometry is shown and can be used for both "omics" and in vitro studies.
Journal ArticleDOI
Myeloid cells in metastasis
TL;DR: This review describes the currently reported pathways and mechanisms involved in myeloid cell enhancement of the metastatic cascade and opens new avenues for targeting cancer metastasis.