A
Antonella Fidanza
Researcher at University of Edinburgh
Publications - 21
Citations - 770
Antonella Fidanza is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Induced pluripotent stem cell & Haematopoiesis. The author has an hindex of 8, co-authored 17 publications receiving 434 citations. Previous affiliations of Antonella Fidanza include University of Teramo.
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Journal ArticleDOI
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
Luca Cassetta,Stamatina Fragkogianni,Andrew H. Sims,Agnieszka Swierczak,Lesley M. Forrester,Hui Zhang,Daniel Y.H. Soong,Tiziana Cotechini,Pavana Anur,Elaine Y. Lin,Antonella Fidanza,Martha Lopez-Yrigoyen,Michael Millar,Alexandra Urman,Zhichao Ai,Paul T. Spellman,E. Shelley Hwang,J Michael Dixon,Lisa Wiechmann,Lisa M. Coussens,Harriet O. Smith,Jeffrey W. Pollard,Jeffrey W. Pollard +22 more
TL;DR: It is shown that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer and an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8 is identified.
Journal ArticleDOI
Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
Martha Lopez-Yrigoyen,Cheng-Tao Yang,Antonella Fidanza,Luca Cassetta,A. Helen Taylor,Angela McCahill,Erica Sellink,Marieke von Lindern,Emile van den Akker,Joanne C. Mountford,Jeffrey W. Pollard,Lesley M. Forrester +11 more
TL;DR: An in vitro system to model the human EI niche is established using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.
Journal ArticleDOI
Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.
Cheng-Tao Yang,Rui Ma,Richard A Axton,Melany Jackson,A. Helen Taylor,Antonella Fidanza,Lamin Marenah,Lamin Marenah,Jan Frayne,Joanne C. Mountford,Joanne C. Mountford,Lesley M. Forrester +11 more
TL;DR: This study demonstrates the successful use of an inducible genetic programing strategy that could be applied to the production of many other cell lineages from human induced pluripotent stem cells with the integration of programming factors into the AAVS1 locus providing a safer and more reproducible route to the clinic.
Journal ArticleDOI
Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs.
Antonella Fidanza,Patrick S. Stumpf,Prakash Ramachandran,Sara Tamagno,Ann C. Babtie,Martha Lopez-Yrigoyen,A. Helen Taylor,Jennifer Easterbrook,Beth E. P. Henderson,Richard A Axton,Neil C. Henderson,Alexander Medvinsky,Katrin Ottersbach,Nicola Romanò,Lesley M. Forrester +14 more
TL;DR: By comparing the single cell transcriptome of in vitro-generated HSC-like cells with those generated within the fetal liver, it is identified transcription factors and molecular pathways that can be exploited in the future to improve the in vitro production of HSCs.
Journal ArticleDOI
A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells.
Martha Lopez-Yrigoyen,Antonella Fidanza,Luca Cassetta,Richard A Axton,A. Helen Taylor,Jose Meseguer-Ripolles,Anestis Tsakiridis,Valerie Wilson,David C. Hay,Jeffrey W. Pollard,Lesley M. Forrester +10 more
TL;DR: Targeting of the AAVS1 locus in iPSCs allows for the production of fully functional, fluorescently tagged human macrophages that can be used for in vivo tracking in disease models and provides a platform for the introduction of factors predicted to modulate and/or stabilize macrophage function.