L
Lesley M. Forrester
Researcher at University of Edinburgh
Publications - 79
Citations - 4650
Lesley M. Forrester is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 29, co-authored 75 publications receiving 3974 citations. Previous affiliations of Lesley M. Forrester include Mount Sinai Hospital, Toronto & Bristol-Myers Squibb.
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Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Erik Arner,Carsten O. Daub,Kristoffer Vitting-Seerup,Robin Andersson,Berit Lilje,Finn Drabløs,Andreas Lennartsson,Michelle Rönnerblad,Olga Hrydziuszko,Morana Vitezic,Tom C. Freeman,Ahmad M. N. Alhendi,Peter Arner,Richard A Axton,J Kenneth Baillie,Anthony G Beckhouse,Beatrice Bodega,James Briggs,Frank Brombacher,Margaret B. Davis,Michael Detmar,Anna Ehrlund,Mitsuhiro Endoh,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Dan Goldowitz,Reto Guler,Thomas J. Ha,Mitsuko Hara,Meenhard Herlyn,Tomokatsu Ikawa,Chieko Kai,Hiroshi Kawamoto,Levon M. Khachigian,S. Peter Klinken,Soichi Kojima,Haruhiko Koseki,Sarah Klein,Niklas Mejhert,Ken Miyaguchi,Yosuke Mizuno,Mitsuru Morimoto,Kelly J. Morris,Christine L. Mummery,Yutaka Nakachi,Soichi Ogishima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Xian-Yang Qin,Sugata Roy,Hiroki Sato,Suzana Savvi,Alka Saxena,Anita Schwegmann,Daisuke Sugiyama,Rolf Swoboda,Hiroshi Tanaka,Andru Tomoiu,Louise N. Winteringham,Ernst J. Wolvetang,Chiyo Yanagi-Mizuochi,Misako Yoneda,Susan E. Zabierowski,Peter G. Zhang,Imad Abugessaisa,Nicolas Bertin,Alexander D. Diehl,Shiro Fukuda,Masaaki Furuno,Jayson Harshbarger,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Yuri Ishizu,Masayoshi Itoh,Tsugumi Kawashima,Miki Kojima,Naoto Kondo,Marina Lizio,Terrence F. Meehan,Christopher J. Mungall,Mitsuyoshi Murata,Hiromi Nishiyori-Sueki,Serkan Sahin,Sayaka Nagao-Sato,Jessica Severin,Michiel J. L. de Hoon,Jun Kawai,Takeya Kasukawa,Timo Lassmann,Harukazu Suzuki,Hideya Kawaji,Kim M. Summers,Christine A. Wells,David A. Hume,Alistair R. R. Forrest,Albin Sandelin,Piero Carninci,Yoshihide Hayashizaki +108 more
TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
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Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
Luca Cassetta,Stamatina Fragkogianni,Andrew H. Sims,Agnieszka Swierczak,Lesley M. Forrester,Hui Zhang,Daniel Y.H. Soong,Tiziana Cotechini,Pavana Anur,Elaine Y. Lin,Antonella Fidanza,Martha Lopez-Yrigoyen,Michael Millar,Alexandra Urman,Zhichao Ai,Paul T. Spellman,E. Shelley Hwang,J Michael Dixon,Lisa Wiechmann,Lisa M. Coussens,Harriet O. Smith,Jeffrey W. Pollard,Jeffrey W. Pollard +22 more
TL;DR: It is shown that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer and an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8 is identified.
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Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells
Melany Jackson,Anna Krassowska,Nick Gilbert,Timothy Chevassut,Lesley M. Forrester,J. D. Ansell,Bernard Ramsahoye +6 more
TL;DR: It is shown that successful terminal differentiation is not dependent simply on adequate methylation levels, and there is an absolute requirement that the methylation be delivered by the maintenance enzyme Dnmt1.
Journal ArticleDOI
W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor
TL;DR: It is demonstrated that the pleiotropic developmental defects associated with the W/c-kit locus arise as the result of dominant loss-of-function mutations in a transmembrane receptor tyrosine kinase.
Journal ArticleDOI
Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches
Maria H. Ledran,Anna Krassowska,Lyle Armstrong,Ian Dimmick,Jonas Renström,Roland Lang,Sun Yung,Mauro Santibanez-Coref,Elaine Dzierzak,Miodrag Stojkovic,Robert A.J. Oostendorp,Lesley M. Forrester,Majlinda Lako +12 more
TL;DR: Investigation of coculture with monolayers of cells derived from mouse AGM and fetal liver, or with stromal cell lines derived from these tissues, found that under such conditions hESC-derived differentiating cells formed early hematopoietic progenitors, with a peak at day 18-21 of differentiation that corresponded to the highest CD34 expression.