Ahmet Civas

TL;DR: It is shown that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1 β (IL-1β).

TL;DR: This review will focus on RIG-I-like receptor (RLR) signal transduction and the regulatory mechanisms - ubiquitination, deubiquitinations, ISGylation - underlying this important host response to virus infection.

TL;DR: New data describing how IRF3 and IRF7 regulate the temporal and quantitative differences in the expression of the multigenic IFN-A family enhances the understanding of the selective advantage of the multiplicity ofIFN-alpha subtypes in the regulation of innate and adaptive immunity.

TL;DR: This regulatory mechanism contributes to differential expression of IFN-A genes and may be critical for alpha interferon production in different cell types by RIG-I-dependent signals, leading to innate antiviral immune responses.

TL;DR: Treatment of cells with trichostatin A (TSA), a deacetylase inhibitor, inhibits the virus-induced activation of IFN-α/β promoters and dramatically reduces the ability of different ISG promoters to respond to IFN stimulation, suggesting that an acetylation/deacetylation mechanism participates in the regulation of cellular distribution and function of STAT2 in IFn- α/β signaling.