J
Jean-Luc Perfettini
Researcher at Institut Gustave Roussy
Publications - 60
Citations - 7329
Jean-Luc Perfettini is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 28, co-authored 56 publications receiving 6598 citations. Previous affiliations of Jean-Luc Perfettini include French Institute of Health and Medical Research & University of Paris-Sud.
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Journal ArticleDOI
Inhibition of macroautophagy triggers apoptosis.
Patricia Boya,Rosa-Ana Gonzalez-Polo,Noelia Casares,Jean-Luc Perfettini,Philippe Dessen,Nathanael Larochette,Didier Métivier,Daniel Meley,Sylvie Souquère,Tamotsu Yoshimori,Gérard Pierron,Patrice Codogno,Guido Kroemer +12 more
TL;DR: Data indicate that autophagy may be cytoprotective, at least under conditions of nutrient depletion, and point to an important cross talk between type 1 and type 2 cell death pathways.
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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
François Ghiringhelli,Lionel Apetoh,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Laetitia Aymeric,Laetitia Aymeric,Laetitia Aymeric,Yuting Ma,Yuting Ma,Yuting Ma,Carla Ortiz,Karim Vermaelen,Theocharis Panaretakis,Theocharis Panaretakis,Theocharis Panaretakis,Grégoire Mignot,Evelyn Ullrich,Evelyn Ullrich,Evelyn Ullrich,Jean-Luc Perfettini,Jean-Luc Perfettini,Jean-Luc Perfettini,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Ezgi Tasdemir,Ezgi Tasdemir,Ezgi Tasdemir,Martin Uhl,Pierre Génin,Ahmet Civas,Bernhard Ryffel,Jean Kanellopoulos,Jürg Tschopp,Fabrice Andre,Fabrice Andre,Fabrice Andre,Rosette Lidereau,Nicole McLaughlin,Nicole M. Haynes,Mark J. Smyth,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +45 more
TL;DR: It is shown that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1 β (IL-1β).
Journal ArticleDOI
Cell death by mitotic catastrophe : a molecular definition
Maria Castedo,Jean-Luc Perfettini,Thomas Roumier,Karine Andreau,René H. Medema,Guido Kroemer +5 more
TL;DR: It is proposed that mitotic catastrophe results from a combination of deficient cell-cycle checkpoints and cellular damage and failure to arrest the cell cycle before or at mitosis triggers an attempt of aberrant chromosome segregation, which culminates in the activation of the apoptotic default pathway and cellular demise.
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Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
Maria Castedo,Jean-Luc Perfettini,Thomas Roumier,Alexander Valent,Hana Raslova,Kenichi Yakushijin,David A. Horne,Jean Feunteun,Gilbert M. Lenoir,René H. Medema,William Vainchenker,Guido Kroemer +11 more
TL;DR: A molecular pathway through which DNA damage, failure to arrest the cell cycle and inhibition of apoptosis can favor the occurrence of cytogenetic abnormalities that are likely to participate in oncogenesis is delineated.
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Chemotherapy induces ATP release from tumor cells.
Isabelle Martins,Antoine Tesniere,Oliver Kepp,Mickaël Michaud,Frédéric Schlemmer,Laura Senovilla,Claire Séror,Didier Métivier,Jean-Luc Perfettini,Laurence Zitvogel,Guido Kroemer +10 more
TL;DR: It is described that multiple distinct anticancer drugs reduce the intracellular concentration of ATP before and during the manifestation of apoptotic characteristics such as the dissipation of the mitochondrial transmembrane potential and the exposure of phosphatidylserine residues on the plasma membrane.