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Áine McKnight
Researcher at Queen Mary University of London
Publications - 106
Citations - 7158
Áine McKnight is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 37, co-authored 87 publications receiving 5667 citations. Previous affiliations of Áine McKnight include Duke University & Institute of Cancer Research.
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Journal ArticleDOI
CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4
Michael J. Endres,Paul R. Clapham,Mark Marsh,Ména Ahuja,Julie D. Turner,Áine McKnight,Jill F Thomas,Beth Stoebenau-Haggarty,Sunny Choe,Patricia J. Vance,Timothy N. C. Wells,Christine A. Power,Shaheen S Sutterwala,Robert W. Doms,Nathaniel R. Landau,James A. Hoxie +15 more
TL;DR: The finding that one chemokine receptor can function as a primary viral receptor strongly suggests that the HIV envelope glycoprotein contains a binding site for these proteins and that differences in the affinity and/or the availability of this site can extend the host range of these viruses to include a number of CD4-negative cell types.
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Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
Davide Corti,Johannes P. M. Langedijk,Andreas Hinz,Michael S. Seaman,Fabrizia Vanzetta,Blanca Fernandez-Rodriguez,Chiara Silacci,Debora Pinna,David Jarrossay,Sunita S. Balla-Jhagjhoorsingh,B. Willems,Maria J. Zekveld,Hanna Dreja,Eithne O'Sullivan,Corinna Pade,Chloe Orkin,Simon A. Jeffs,David C. Montefiori,David Davis,Winfried Weissenhorn,Áine McKnight,Jonathan L. Heeney,Federica Sallusto,Quentin J. Sattentau,Robin A. Weiss,Antonio Lanzavecchia +25 more
TL;DR: This study reveals that by using appropriate screening methods, a large proportion of memory B cells can be isolated that produce mAbs with HIV-1 neutralizing activity, and three of these mAbs show unusual breadth of neutralization and therefore add to the current panel of HIV- 1 neutralizing antibodies with potential for passive protection and template-based vaccine design.
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Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals.
Charlotte Manisty,Ashley Otter,Thomas A. Treibel,Áine McKnight,Daniel M. Altmann,Timothy Brooks,Mahdad Noursadeghi,Rosemary J. Boyton,Amanda Semper,James C. Moon +9 more
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COVID-19: PCR screening of asymptomatic health-care workers at London hospital.
Thomas A. Treibel,Charlotte Manisty,Charlotte Manisty,Maudrian Burton,Áine McKnight,Jonathan Lambourne,João B Augusto,João B Augusto,Xose Couto-Parada,Teresa Cutino-Moguel,Mahdad Noursadeghi,James C. Moon,James C. Moon +12 more
Journal ArticleDOI
Cell surface receptors, virus entry and tropism of primate lentiviruses.
Paul R. Clapham,Áine McKnight +1 more
TL;DR: This review describes cell surface receptors, their roles in HIV entry and their influence on cell tropism.