A
Ajit Shah
Researcher at University of California, San Francisco
Publications - 14
Citations - 671
Ajit Shah is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Heme & Beta cell. The author has an hindex of 8, co-authored 14 publications receiving 440 citations. Previous affiliations of Ajit Shah include University of Texas Southwestern Medical Center & University of Texas at Dallas.
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Journal ArticleDOI
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Peter Thompson,Ajit Shah,Vasilis Ntranos,Vasilis Ntranos,Frédéric Van Gool,Mark A. Atkinson,Anil Bhushan +6 more
TL;DR: It is shown that during the natural history of T1D in humans and the non-obese diabetic (NOD) mouse model, a subset of beta cells acquires a senescence-associated secretory phenotype (SASP), and clearance of senescent beta cells could be a new therapeutic approach for T1d.
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Heme, an Essential Nutrient from Dietary Proteins, Critically Impacts Diverse Physiological and Pathological Processes
TL;DR: Both epidemiological and molecular studies support the idea that heme positively impacts cancer progression, and the role of dietary heme intake and heme function in diverse diseases is summarized.
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Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells
Jagmohan Hooda,Daniela Cadinu,Maksudul Alam,Ajit Shah,Thai M. Cao,Laura A. Sullivan,Rolf A. Brekken,Li Zhang +7 more
TL;DR: The results show that inhibiting heme and respiratory function can effectively arrest the progression of lung cancer cells and understanding heme function can positively impact on research in lung cancer biology and therapeutics.
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mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes
Rami Jaafar,Stella Tran,Ajit Shah,Gao Sun,Martin Valdearcos,Piero Marchetti,Matilde Masini,Avital Swisa,Simone Giacometti,Ernesto Bernal-Mizrachi,Aleksey V. Matveyenko,Matthias Hebrok,Yuval Dor,Guy A. Rutter,Suneil K. Koliwad,Anil Bhushan +15 more
TL;DR: Manipulating the way in which cellular nutrient signaling pathways regulate β- cell metabolism may offer new targets to improve β-cell function in diabetes.
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The Nuclear Localization of SWI/SNF Proteins Is Subjected to Oxygen Regulation
TL;DR: SWI/SNF proteins relocalize in response to hypoxia and reoxygenation in a quick manner, and their relocalization likely accounts for, in part or in whole, oxygen regulation of many SWI/ SNF target genes.