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Anil Bhushan
Researcher at University of California, San Francisco
Publications - 59
Citations - 6055
Anil Bhushan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cell cycle & Cellular differentiation. The author has an hindex of 35, co-authored 58 publications receiving 5362 citations. Previous affiliations of Anil Bhushan include Sher-e-Kashmir University of Agricultural Sciences and Technology & French Institute of Health and Medical Research.
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Journal ArticleDOI
β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans
Juris J. Meier,Alexandra E. Butler,Yoshifumi Saisho,Travis Monchamp,Ryan Galasso,Anil Bhushan,Robert A. Rizza,Peter C. Butler +7 more
TL;DR: Data imply that regulation of β- cell replication during infancy plays a major role in β-cell mass in adult humans.
Journal ArticleDOI
β cell replication is the primary mechanism for maintaining postnatal β cell mass
Senta Georgia,Anil Bhushan +1 more
TL;DR: It is demonstrated that cyclin D2 is required for the replication of endocrine cells but is expendable for exocrine and ductal cell replication and may provide a target for the development of therapeutic strategies to induce expansion and/or regeneration of β cells.
Journal ArticleDOI
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?
TL;DR: It is concluded that type 1 diabetes may be reversed by targeted inhibition of beta cell destruction, and the mechanisms underlying increased beta cell death may involve both ongoing autoimmunity and glucose toxicity.
Journal ArticleDOI
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
Anil Bhushan,Nobuyuki Itoh,Shigeaki Kato,Jean P. Thiery,Paul Czernichow,Saverio Bellusci,Raphael Scharfmann +6 more
TL;DR: It is demonstrated here that Fgf10, a member of the fibroblast growth factor family (FGFs), plays an essential role in the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells.
Journal ArticleDOI
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
Gopika G. Nair,Jennifer S. Liu,Holger A. Russ,Holger A. Russ,Stella Tran,Stella Tran,Michael S Saxton,Richard Chen,Charity Juang,Mei-Lan Li,Vinh Son Nguyen,Simone Giacometti,Sapna Puri,Yuan Xing,Yong Wang,Gregory L. Szot,Jose Oberholzer,Anil Bhushan,Matthias Hebrok +18 more
TL;DR: Replicating aspects of endocrine cell clustering permits the generation of stem-cell-derived β cells that resemble their endogenous counterparts, including robust dynamic insulin secretion and mitochondrial oxidative respiration.